ArticleNature communications2020
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Reference range of naïve T and T memory lymphocyte subsets in peripheral blood of healthy adult.Clinical and experimental immunology · 2022Trial
- T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy.Signal transduction and targeted therapy · 2026Review
- Distribution and function of human long-lasting T cells in aging and non-small cell lung cancer.Frontiers in immunology · 2026Review
- Wnt signaling as a regulator of memory T cells: implications for CAR-T cell therapy.Frontiers in immunology · 2026Review
- Shaping the founders: naïve CD4 T cell heterogeneity in people with HIV-1 or HIV-2.Frontiers in immunology · 2026Article
- Identification EXOSC4 as a novel autoantigen of interstitial lung disease in rheumatoid arthritis.Journal of translational medicine · 2025Article
- T Cell Aging: An Important Target for Perioperative Immunomodulation.Clinical interventions in aging · 2025Review
- SLAMF7 defines subsets of human effector CD8 T cells.Scientific reports · 2024Article
- Article
- From Genesis to Old Age: Exploring the Immune System One Cell at a Time with Flow Cytometry.Biomedicines · 2024Review
- Memory stem CD8Frontiers in cellular and infection microbiology · 2024Review
- A strategy to reconstitute immunity without GVHD via adoptive allogeneic Tscm therapy.Frontiers in immunology · 2024Article
- SIRT2 inhibition by AGK2 enhances mycobacteria-specific stem cell memory responses by modulating beta-catenin and glycolysis.iScience · 2023Article
- Article
- T memory stem cell characteristics in autoimmune diseases and their promising therapeutic values.Frontiers in immunology · 2023Review
- T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications.Frontiers in immunology · 2023Review
- Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells.Cancer gene therapy · 2022Article
- Article
- An Abnormal Inflammatory Pattern Associated with Long-Term Non-Progression of HIV Infection Impacts Negatively on Bone Quality.Journal of clinical medicine · 2022Article
- Understanding T cell aging to improve anti-viral immunity.Current opinion in virology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Hassen KaredSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore. hassen.acn@gmail.com.ORCID http://orcid.org/0000-0002-8220-997X
Shu Wen TanSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Mai Chan LauSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Marion ChevrierSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.ORCID http://orcid.org/0000-0002-9157-8312
Crystal TanSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Wilson HowSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Glenn WongSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Marie StricklandSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.ORCID http://orcid.org/0000-0002-1922-8457
Benoit MalleretSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.ORCID http://orcid.org/0000-0001-9658-7528
Amanda AmoahInstitute of Molecular Medicine, University of Ulm, Ulm, Germany.
Karolina PilipowHumanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI), Rozzano, Italy.
Veronica ZanonHumanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI), Rozzano, Italy.
Naomi Mc GovernSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Josephine LumSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Jin Miao ChenSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Bernett LeeSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.
Maria Carolina FlorianInstitute of Molecular Medicine, University of Ulm, Ulm, Germany.
Hartmut GeigerInstitute of Molecular Medicine, University of Ulm, Ulm, Germany.
Florent GinhouxSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore.ORCID http://orcid.org/0000-0002-2857-7755
Ezequiel Ruiz-MateosClinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
Tamas FulopDepartment of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada.
Reena RajasuriarCentre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia.
Adeeba KamarulzamanCentre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia.
Tze Pin NgGerontology Research Programme and Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Enrico LugliHumanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI), Rozzano, Italy.ORCID http://orcid.org/0000-0002-1964-7678
Anis LarbiSingapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, 8A Biomedical Grove, Biopolis, Republic of Singapore. anis_larbi@immunol.a-star.edu.sg.
Funding
NIEHS NIH HHS 27300C0032
Abstract
The diversity of the naïve T cell repertoire drives the replenishment potential and capacity of memory T cells to respond to immune challenges. Attrition of the immune system is associated with an increased prevalence of pathologies in aged individuals, but whether stem cell memory T lymphocytes (T
Indexed as
AgingAnimalsAntigens, CDbeta CateninCD4-Positive T-LymphocytesGene Expression ProfilingHIV InfectionsHumansImmunologic MemoryIntercellular Signaling Peptides and ProteinsMicePrecursor Cells, T-LymphoidThymus GlandWnt Signaling PathwayAntigens, CDbeta CateninDKK1 protein, humanIntercellular Signaling Peptides and Proteins
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.