Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Colocalized White Matter Plasticity and Increased Cerebral Blood Flow Mediate the Beneficial Effect of Cardiovascular Exercise on Long-Term Motor Learning.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Comparative efficacy of cognitive training modalities in cognitive impairment: A systematic review and network meta-analysis.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis.Brain imaging and behavior · 2022Pooled it
- A Systematic Review of the Impact of Physical Exercise-Induced Increased Resting Cerebral Blood Flow on Cognitive Functions.Frontiers in aging neuroscience · 2022Pooled it
- Acute cardiovascular exercise diminishes the consolidation of a complex whole-body task in young adults.Experimental brain research · 2026Trial
- Online stimulation of the prefrontal cortex during practice increases motor variability and modulates later cognitive transfer: a randomized, double-blinded and sham-controlled tDCS study.Scientific reports · 2024Trial
- Priming cardiovascular exercise improves complex motor skill learning by affecting the trajectory of learning-related brain plasticity.Scientific reports · 2022Trial
- Aerobic exercise and aerobic fitness level do not modify motor learning.Scientific reports · 2021Trial
- Effects of Baduanjin combined with cognitive training in older adults with mild cognitive impairment of mixed etiologies: a study protocol for a randomized controlled trial.BMC geriatrics · 2026Article
- Multiscale Mechanisms of Exercise-Induced Neuroplasticity: From Molecular Pathways to Network Dynamics and Behavioral Adaptation.Brain sciences · 2026Review
- Motor learning induces myelin-related white matter changes revealed by MRI-based in vivo histology.Communications biology · 2026Article
- The relationship between physical exercise and learning engagement among chinese college students: the chain mediating roles of cognitive flexibility and psychological resilience.Frontiers in psychology · 2026Article
- Systemic relationships between ecological-dynamic approach and active reflection: psycho-neuro-motor, cognitive, and physiological interactions in rugby pedagogy.Frontiers in sports and active living · 2026Article
- Cardiovascular exercise enhances motor learning across multiple sessions in people with Parkinson's disease: a randomized controlled pilot trial.NPJ science of learning · 2025Article
- Neuroplasticity of Brain Networks Through Exercise: A Narrative Review About Effect of Types, Intensities, and Durations.Sports (Basel, Switzerland) · 2025Review
- Effects of Aging, Estimated Fitness, and Cerebrovascular Status on White Matter Microstructural Health.Human brain mapping · 2025Article
- Longitudinal Changes of Quantitative Brain Tissue Properties Induced by Balance Training.Human brain mapping · 2025Article
- Cerebral arterial blood flow, attention, and executive and cognitive functions in depressed patients after acute hypertensive cerebral hemorrhage.World journal of clinical cases · 2024Article
- Higher surface folding of the human premotor cortex is associated with better long-term learning capability.Communications biology · 2024Article
- Gray matter volume of functionally relevant primary motor cortex is causally related to learning a hand motor task.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Changes in Cortical Microstructure of the Human Brain Resulting from Long-Term Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular exercise (CE) is a promising intervention strategy to facilitate cognition and motor learning in healthy and diseased populations of all ages. CE elevates humoral parameters, such as growth factors, and stimulates brain changes potentially relevant for learning and behavioral adaptations. However, the causal relationship between CE-induced brain changes and human's ability to learn remains unclear. We tested the hypothesis that CE elicits a positive effect on learning via alterations in brain structure (morphological changes of gray and white matter) and function (functional connectivity and cerebral blood flow in resting state). We conducted a randomized controlled trial with healthy male and female human participants to compare the effects of a 2 week CE intervention against a non-CE control group on subsequent learning of a challenging new motor task (dynamic balancing; DBT) over 6 consecutive weeks. We used multimodal neuroimaging [T1-weighted magnetic resonance imaging (MRI), diffusion-weighted MRI, perfusion-weighted MRI, and resting state functional MRI] to investigate the neural mechanisms mediating between CE and learning. As expected, subjects receiving CE subsequently learned the DBT at a higher rate. Using a modified nonparametric combination approach along with multiple mediator analysis, we show that this learning boost was conveyed by CE-induced increases in cerebral blood flow in frontal brain regions and changes in white matter microstructure in frontotemporal fiber tracts. Our study revealed neural mechanisms for the CE-learning link within the brain, probably allowing for a higher flexibility to adapt to highly novel environmental stimuli, such as learning a complex task.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.