ArticleCancer research2020
Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity.
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Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Nutritional Prevention of Oxidative Stress-Induced Cardiotoxicity in Pediatric Cardio-Oncology: Molecular Mechanisms and Translational Perspectives-A Narrative Review.International journal of molecular sciences · 2026Review
- The dual role of vitamin C in cancer: from antioxidant prevention to prooxidant therapeutic applications.Frontiers in medicine · 2025Review
- Redox-active vitamin C suppresses human osteosarcoma growth by triggering intracellular ROS-iron-calcium signaling crosstalk and mitochondrial dysfunction.Redox biology · 2024Article
- Hydrogen Peroxide Mediates Pharmacological Ascorbate Induced Radio-Sensitization of Pancreatic Cancer Cells by Enhancing G2-accumulation and Reducing Cyclin B1 Protein Levels.Radiation research · 2023Article
- Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage.Antioxidants (Basel, Switzerland) · 2023Article
- Pharmacologic Ascorbate and DNMT Inhibitors Increase DUOX Expression and Peroxide-Mediated Toxicity in Pancreatic Cancer.Antioxidants (Basel, Switzerland) · 2023Article
- Pharmacological ascorbate induces sustained mitochondrial dysfunction.Free radical biology & medicine · 2023Article
- Manipulation of Redox Metabolism Using Pharmacologic Ascorbate Opens a Therapeutic Window for Radio-Sensitization by ATM Inhibitors in Colorectal Cancer.International journal of radiation oncology, biology, physics · 2023Article
- Review
- Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids.Scientific reports · 2022Article
- Modeling pancreatic cancer in mice for experimental therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2021Review
- Impact of EcSOD Perturbations in Cancer Progression.Antioxidants (Basel, Switzerland) · 2021Review
- Epigenetic effects of pharmacologic ascorbate.Oncotarget · 2021Article
- Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate.Antioxidants (Basel, Switzerland) · 2021Article
- Review
- Two Distinct Faces of Vitamin C: AA vs. DHA.Antioxidants (Basel, Switzerland) · 2021Review
- TLR4-Dependent DUOX2 Activation Triggered Oxidative Stress and Promoted HMGB1 Release in Dry Eye.Frontiers in medicine · 2021Article
- Comprehensive Subchronic Inhalation Toxicity Assessment of an Indoor School Air Mixture of PCBs.Environmental science & technology · 2020Article
- Ascorbic acid (vitamin C) synergistically enhances the therapeutic effect of targeted therapy in chronic lymphocytic leukemia.Journal of experimental & clinical cancer research : CR · 2020Article
- Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Adrienne R GibsonFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa.
Brianne R O'LearyFree Radical and Radiation Biology Division, Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, Iowa.
Juan DuFree Radical and Radiation Biology Division, Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, Iowa.
Ehab H SarsourKansas City University of Medicine and Biosciences, Kansas City, Missouri.
Amanda L KalenFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa.
Brett A WagnerFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa.ORCID 0000-0002-0094-7259
Jeffrey M StolwijkFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa.ORCID 0000-0001-6281-0103
Kelly C Falls-HubertFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa.
Matthew S AlexanderFree Radical and Radiation Biology Division, Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, Iowa.ORCID 0000-0001-6119-6324
Rory S CarrollFree Radical and Radiation Biology Division, Department of Surgery, The University of Iowa Carver College of Medicine, Iowa City, Iowa.
Douglas R SpitzFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa.ORCID 0000-0002-1254-8765
Garry R BuettnerFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa.ORCID 0000-0002-5594-1903
Prabhat C GoswamiFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa.
Joseph J CullenFree Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, Iowa. joseph-cullen@uiowa.edu.
University of Iowa · USKansas City University · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MProject 4: New Approaches to Improving the Effectiveness of Radionuclide Targeted Treatments in Neuroendocrine TumorsP50CA174521 · NCI · UNIVERSITY OF IOWA · PI ODORISIO, THOMAS · 2015 to 2021
$13.2MProject 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUETTNER, GARRY R · 2018 to 2022
$9.6MUniversity of Iowa Surgical Oncology Training GrantT32CA148062 · NCI · UNIVERSITY OF IOWA · PI WEIGEL, RONALD J · 2010 to 2020
$3.8MEnhancing Metabolic Oxidative Stress and Therapy Responses in Cancer Stem CellsR01CA182804 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 2014 to 2018
$1.7MThe chemical biology of pharmacological ascorbate in cancer treatmentR01CA169046 · NCI · UNIVERSITY OF IOWA · PI BUETTNER, GARRY R · 2013 to 2017
$1.6MPharmacological Ascorbate as a Radiosensitizer in Pancreatic CancerR01CA184051 · NCI · UNIVERSITY OF IOWA · PI CULLEN, JOSEPH J · 2015 to 2018
$1.4MTargeting lung and breast cancer cell oxidative metabolism with D-penicillamine and disulfiramF30CA213817 · NCI · UNIVERSITY OF IOWA · PI HUBERT, KELLY · 2017 to 2020
$162kNCI NIH HHS F30 CA213817NCI NIH HHS P01 CA217797NCI NIH HHS P30 CA086862NCI NIH HHS P50 CA174521NCI NIH HHS R01 CA169046NCI NIH HHS R01 CA182804NCI NIH HHS R01 CA184051NCI NIH HHS T32 CA148062NIEHS NIH HHS P30 ES005605NIGMS NIH HHS T32 GM007337
Abstract
Pharmacologic ascorbate treatment (P-AscH
Indexed as
Administration, IntravenousAnimalsAscorbic AcidCarcinoma, Pancreatic DuctalCell Line, TumorChemotherapy, AdjuvantDose-Response Relationship, DrugDown-RegulationDual OxidasesGene Expression Regulation, NeoplasticHumansHydrogen PeroxideMiceOxidative StressOxygenOxygen ConsumptionAscorbic AcidDual OxidasesDUOX1 protein, humanDUOX2 protein, humanHydrogen PeroxideOxygenReactive Oxygen Species
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.