Evidence map›Paper›PMID 32041742›Full record

ArticleeNeuro

Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure.

Abigail E Agoglia, ManHua Zhu, Rose Ying, Harpreet Sidhu, Luis A Natividad, Sarah A Wolfe, Matthew W Buczynski, Candice Contet, Loren H Parsons, Marisa Roberto and 1 more

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Abigail E AgogliaDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
ManHua ZhuNeuroscience Curriculum, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
Rose YingDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
Harpreet SidhuDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California 92037.
Luis A NatividadUniversity of Texas at Austin, College of Pharmacy - Division of Pharmacology and Toxicology, Austin, TX 78712.
Sarah A WolfeDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California 92037.
Matthew W BuczynskiSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061.
Candice ContetDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California 92037.ORCID 0000-0002-4459-9540
Loren H ParsonsDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California 92037.
Marisa RobertoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California 92037.
Melissa A HermanDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 melissa_herman@unc.edu.
Scripps Research Institute · USUniversity of North Carolina at Chapel Hill · USAustin College · USVirginia Tech · US

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ERIC P ZORRILLA · 2003 to 2026
$46.3M
UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A Herman · 2003 to 2026
$46.3M
Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
RESEARCH TRAINING IN THE NEUROSCIENCEST32NS007431 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juan Song, Mark J. Zylka · 1997 to 2026
$10.0M
Supplement to Molecular and Cellular Studies on Alcohol's ActionsT32AA007573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FULTON T CREWS, Thomas L. Kash · 1997 to 2026
$9.3M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI HENRIKSEN, STEVEN J · 1985 to 2002
$5.1M
MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISMP50AA011605 · NIAAA · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI CREWS, FULTON T · 1998 to 2002
$4.9M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Activation of the parasubthalamic nucleus in alcohol dependenceR01AA026685 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Jeffery Lee Dunning · 2018 to 2026
$3.0M
NIAAA NIH HHS F32 AA024952NIAAA NIH HHS K99 AA023002NIAAA NIH HHS K99 AA025393NIAAA NIH HHS P50 AA006420NIAAA NIH HHS P50 AA011605NIAAA NIH HHS P60 AA006420NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R00 AA023002NIAAA NIH HHS R00 AA025393NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA016985NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R01 AA026685NIAAA NIH HHS R01 AA027700NIAAA NIH HHS T32 AA007456NIAAA NIH HHS T32 AA007573NIAAA NIH HHS U01 AA013498NINDS NIH HHS T32 NS007431
6 · The paper itself

Abstract

The lateral amygdala (LA) serves as the point of entry for sensory information within the amygdala complex, a structure that plays a critical role in emotional processes and has been implicated in alcohol use disorders. Within the amygdala, the corticotropin-releasing factor (CRF) system has been shown to mediate some of the effects of both stress and ethanol, but the effects of ethanol on specific CRF1 receptor circuits in the amygdala have not been fully established. We used male CRF1:GFP reporter mice to characterize CRF1-expressing (CRF1

Indexed as

AlcoholismEthanolAmygdalaAnimalsCorticotropin-Releasing HormoneCRF Receptor, Type 1gamma-Aminobutyric AcidMaleMiceNeuronsReceptors, Corticotropin-Releasing HormoneCorticotropin-Releasing HormoneCRF Receptor, Type 1Ethanolgamma-Aminobutyric AcidReceptors, Corticotropin-Releasing Hormonealcoholbasolateral amygdalaCRFCRF1 receptorGABAlateral amygdala

Identifiers

PMID32041742
PMCPMC7059189
OpenAlexW3005456788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.