ArticleeLife2020
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 242 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
242 citing papers in PubMed, 3 syntheses or guidelines pooled it, 403 citations in OpenAlex.
- Genetic association of the gut microbiota with epigenetic clocks mediated by inflammatory cytokines: a Mendelian randomization analysis.Frontiers in immunology · 2024Pooled it
- The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Pooled it
- DNA methylation aging and transcriptomic studies in horses.Nature communications · 2022Pooled it
- Tai Chi versus health education as a frailty intervention for community-dwelling older adults with hypertension.Aging clinical and experimental research · 2023Trial
- High-Intensity interval training reduces transcriptomic age: A randomized controlled trial.Aging cell · 2023Trial
- Differential DNA methylation clock ages across buffy coat (BC), peripheral blood mononuclear cells (PBMC), and saliva in individuals in early-to-mid adulthood.Epigenetics · 2026Article
- Development and validation of an interpretable Random Forest model for predicting recurrence after endoscopic submucosal dissection in superficial oesophageal squamous cell carcinoma.Annals of medicine · 2026Article
- Associations of breast DNA methylation-based measures of biological ageing with obesity-related breast cancer risk markers.Epigenetics · 2026Article
- Associations of Green Space and Air Pollution Mixture with Heterogeneous Biological Aging Patterns.Environmental health perspectives · 2026Article
- Integrative prediction of Alzheimer's disease and related dementias using multi-omics aging clocks and genetic data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- A generalized approach for estimating the Pace of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Prognostic Value of Different Biological Age Estimation Methods in Breast Cancer Patients: A Population-Based Cohort Study Using NHANES 1999-2020.Health science reports · 2026Article
- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- Socioeconomic inequalities in functional ageing trajectories in England and Canada: A comparative longitudinal cohort study.PLoS medicine · 2026Article
- DXA-Measured Visceral Adipose Tissue and Accelerated Biological Aging in Middle-Aged Adults.Obesity (Silver Spring, Md.) · 2026Article
- Associations between biological age acceleration and hospitalization burden of community-acquired pneumonia: a cohort study.GeroScience · 2026Article
- Longitudinal changes in epigenetic measures over 2 years: methodological implications.GeroScience · 2026Article
- Accelerated biological aging and the risk of incident liver cancer: a prospective cohort study of the UK biobank.BMC gastroenterology · 2026Article
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume.GeroScience · 2026Article
182 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Biological age measurements (BAs) assess aging-related physiological change and predict health risks among individuals of the same chronological age (CA). Multiple BAs have been proposed and are well studied individually but not jointly. We included 845 individuals and 3973 repeated measurements from a Swedish population-based cohort and examined longitudinal trajectories, correlations, and mortality associations of nine BAs across 20 years follow-up. We found the longitudinal growth of functional BAs accelerated around age 70; average levels of BA curves differed by sex across the age span (50-90 years). All BAs were correlated to varying degrees; correlations were mostly explained by CA. Individually, all BAs except for telomere length were associated with mortality risk independently of CA. The largest effects were seen for methylation age estimators (GrimAge) and the frailty index (FI). In joint models, two methylation age estimators (Horvath and GrimAge) and FI remained predictive, suggesting they are complementary in predicting mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.