Trial reportCritical care (London, England)2020
Lactate kinetics in ICU patients using a bolus of
Trial report in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05349370 (Lactate Kinetics in Patients Treated for Septic Shock), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lactate Kinetics in Patients Treated for Septic Shock
Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Lactylation: Metabolic epigenetic regulation and cell death mechanisms in myocardial ischemia‒reperfusion injury.Genes & diseases · 2027Review
- The Oxygen Equivalent of Lactate Accumulation and Sex: Similar Work-Lactate Slopes in Men and Women Regardless of Body or Fat-Free Mass Scaling.FASEB bioAdvances · 2026Article
- A Comprehensive Review of Advanced Lactate Biosensor Materials, Methods, and Applications in Modern Healthcare.Sensors (Basel, Switzerland) · 2025Review
- Hyperglycemia Suppresses Lactate Clearance During Exercise in Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2024Article
- Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets.Frontiers in cardiovascular medicine · 2024Review
- Modeling Challenge Data to Quantify Endogenous Lactate Production.Frontiers in endocrinology · 2021Article
- Lactate Arterial-Central Venous Gradient among COVID-19 Patients in ICU: A Potential Tool in the Clinical Practice.Critical care research and practice · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPlasma lactate concentrations and their trends over time are used for clinical prognosis, and to guide treatment, in critically ill patients. Although heavily relied upon for clinical decision-making, lactate kinetics of these patients is sparsely studied.
aimTo establish and validate a feasible method to study lactate kinetics in critically ill patients.
methodsHealthy volunteers (n = 6) received a bolus dose of
resultsR
conclusionThis simple and user-friendly protocol using an isotopically labeled bolus dose of lactate was accurate and feasible for studying lactate kinetics in critically ill ICU patients.
trial registrationANZCTR, ACTRN12617000626369, registered 8 March 2017. https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372507&isReview=true.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.