Evidence map›Paper›PMID 32041632›Full record

ArticleNutrition journal2020

Vitamin D status in early childhood is not associated with cognitive development and linear growth at 6-9 years of age in North Indian children: a cohort study.

Ranadip Chowdhury, Sunita Taneja, Ingrid Kvestad, Mari Hysing, Nita Bhandari, Tor A Strand

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00717730 (Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections in Young Indian Children), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00717730 phase2completednot on this map

Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections in Young Indian Children

TypeinterventionalSponsorTor A. StrandRan2010 to 2011Enrolled1,000ConditionsDiarrhea, PneumoniaArmsFolic Acid, Vitamin B12, Placebo, Folic acid and vitamin B12
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  16. Nutrition and Brain Development.Current topics in behavioral neurosciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ranadip ChowdhuryCentre for Health Research and Development, Society for Applied Studies, 45, Kalu Sarai, New Delhi, 110016, India. ranadip.chowdhury@sas.org.in.ORCID 0000-0002-0055-6653
Sunita TanejaCentre for Health Research and Development, Society for Applied Studies, 45, Kalu Sarai, New Delhi, 110016, India.
Ingrid KvestadRegional Centre for Child and Youth Mental Health and Child Welfare, West, NORCE Norwegian Research Center, Bergen, Norway.
Mari HysingDepartment of Psychosocial Science, Faculty of Psychology, University of Bergen, Bergen, Norway.
Nita BhandariCentre for Health Research and Development, Society for Applied Studies, 45, Kalu Sarai, New Delhi, 110016, India.
Tor A StrandDepartment of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway.
Society for Applied Studies · INInnlandet Hospital Trust · NONORCE Research AS · NOUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D is important for brain function and linear growth. Vitamin D deficiency during pregnancy has been linked with impaired neurodevelopment during early childhood. However, there is limited evidence from population-based studies on the long-term impact of vitamin D deficiency on cognitive development and linear growth. The objective of the current analysis is to examine whether vitamin D deficiency during infancy and early childhood is associated with cognitive development and linear growth measured in school age.

methodsThis is a follow-up study of a placebo-controlled trial among 1000 North Indian children 6-30 months of age. We measured growth and neurodevelopment in 791 of these children when they were 6-9 years old. Neurodevelopment was measured using the Wechsler Intelligence Scale for Children, 4th edition

resultsAmong the 791 children, baseline vitamin D status was available for 716. Of these, 45.8% were vitamin D deficient, 32.7% were inadequate, and 21.5% were sufficient. Vitamin D status was not associated with any of the cognitive outcomes or linear growth [Adjusted β coefficient for height for age z-score between deficient and sufficient children was - 0.06 (95% CI - 0.24 to 0.11)] at follow up.

conclusionOur findings do not support the notion that poor vitamin D status in early childhood is an important limitation for cognitive development and linear growth.

trial registrationThe trial was first registered at www.clinicaltrials.gov as NCT00717730 in July, 2008, and at CTRI/2010/091/001090 in August, 2010 and then as CTRI/2016/11/007494 in November 2016.

Indexed as

ChildCognitionCognitive DysfunctionCohort StudiesComorbidityFemaleFollow-Up StudiesHumansIndiaMaleVitamin DVitamin D DeficiencyVitamin D4th edition INDIAA developmental neuropsychological assessment IICrichton verbal scaleLinear growthSchool ageThe behavior rating inventory of executive function 2Vitamin DWechsler intelligence scale for children

Identifiers

PMID32041632
PMCPMC7011363
OpenAlexW3005896754

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.