Evidence map›Paper›PMID 32041610›Full record

ArticleCardiovascular diabetology2020

Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes.

Emilie H Zobel, Regitse Højgaard Christensen, Signe A Winther, Philip Hasbak, Christian Stevns Hansen, Bernt J von Scholten, Lene Holmvang, Andreas Kjaer, Peter Rossing, Tine W Hansen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Emilie H ZobelSteno Diabetes Center Copenhagen, Niels Steensens Vej 2, 2820, Gentofte, Denmark. emilie.hein.zobel@regionh.dk.ORCID 0000-0003-3318-7070
Regitse Højgaard ChristensenThe Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark.
Signe A WintherSteno Diabetes Center Copenhagen, Niels Steensens Vej 2, 2820, Gentofte, Denmark.
Philip HasbakDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Christian Stevns HansenSteno Diabetes Center Copenhagen, Niels Steensens Vej 2, 2820, Gentofte, Denmark.
Bernt J von ScholtenSteno Diabetes Center Copenhagen, Niels Steensens Vej 2, 2820, Gentofte, Denmark.
Lene HolmvangDepartment of Cardiology, Rigshospitalet, Copenhagen, Denmark.
Andreas KjaerDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Peter RossingSteno Diabetes Center Copenhagen, Niels Steensens Vej 2, 2820, Gentofte, Denmark.
Tine W HansenSteno Diabetes Center Copenhagen, Niels Steensens Vej 2, 2820, Gentofte, Denmark.
Steno Diabetes Centers · DKUniversity of Copenhagen · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac adipose tissue may have local paracrine effects on epicardial arteries and the underlying myocardium, promoting calcification and affecting myocardial microcirculation. We explored whether the total amount of cardiac adipose tissue was associated with coronary artery calcium score (CAC) and myocardial flow reserve in persons with type 1 or type 2 diabetes and healthy controls.

methodsWe studied three groups: (1) 30 controls, (2) 60 persons with type 1 diabetes and (3) 60 persons with type 2 diabetes. The three groups were matched for sex and age. The three groups derived from retrospective analysis of two clinical studies. All underwent cardiac

resultsMean (SD) cardiac adipose tissue volume was 99 (61) mL in the control group, 106 (78) mL in the type 1 diabetes group and 228 (97) mL in the type 2 diabetes group. Cardiac adipose tissue was positively associated with body mass index in all three groups (p ≤ 0.02). In the controls, cardiac adipose tissue was positively associated with CAC score (p = 0.008) and negatively associated with myocardial flow reserve (p = 0.005). However, cardiac adipose tissue was not associated with CAC or myocardial flow reserve in the groups including persons with type 1 or type 2 diabetes (p ≥ 0.50).

conclusionsIn contrast to what was found in healthy controls, we could not establish a relation between cardiac adipose tissue and coronary calcification or myocardial microvascular function in person with type 1 or type 2 diabetes. The role of cardiac adipose tissue in cardiovascular disease in diabetes remains unclear.

Indexed as

Coronary CirculationMicrocirculationPositron Emission Tomography Computed TomographyAdipose TissueAdiposityCoronary Artery DiseaseDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2HumansPredictive Value of TestsRetrospective StudiesVascular CalcificationAlbuminuriaCardiac adipose tissueCardiac PET/CTCardiac sympathetic innervationCoronary artery calcium scoreEpicardial adipose tissueMIBGMyocardial flow reservePericardial adipose tissueType 1 diabetesType 2 diabetes

Identifiers

PMID32041610
PMCPMC7011555
OpenAlexW3011564737

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.