Evidence map›Paper›PMID 32041568›Full record

ArticleBMC cancer2020

The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer.

Jian Zheng, Xiong Ye, Yanan Liu, Yuxia Zhao, Mudan He, Hui Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Value of circulating tumor cell assisting low-dose computed tomography in screening pulmonary nodules based on existing liquid biopsy techniques: a systematic review with meta-analysis and trial sequential analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jian ZhengDepartment of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.
Xiong YeCollege of Clinical Medicine, Shanghai University of Medicine & Health Science, Shanghai, China.
Yanan LiuDepartment of Clinical Laboratory, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.
Yuxia ZhaoCollege of Clinical Medicine, Shanghai University of Medicine & Health Science, Shanghai, China.
Mudan HeDepartment of Respiratory and Critical Care Medicine, Shanghai First Hospital of Baoshan Branch, Shanghai, China.
Hui XiaoDepartment of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, 85Wujin Road, Shanghai, 200080, China. xiaohui771210@163.com.ORCID http://orcid.org/0000-0002-1465-4596
Shanghai First People's Hospital · CNShanghai University of Medicine and Health Sciences · CNShanghai Children's Hospital · CNShanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China 81701547
6 · The paper itself

Abstract

objectiveSolitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of circulating tumour cells (CTCs) as a marker for the diagnosis of SPNs and the integration of CTCs, carcinoembryonic antigen (CEA) and imaging findings to improve the sensitivity and specificity of diagnosis in patients with SPNs suspected of being lung cancer.

methodFor the serum biomarker assay, the concentration of CEA was measured by an automated electrochemiluminescence analyzer. CTCs were collected from 6 ml of blood by the SE i-FISH method, which detects the gene copy number in eight chromosomes and the tumour-associated antigen CK18.

resultsWith a threshold of 6 CTC units, the method showed a sensitivity of 67.1% and a specificity of 56.5% in the diagnosis of NSCLC, especially in the upper lobe, in which the diagnostic strength was the highest (P < 0.01). CTCs, CEA and nodule type had the highest diagnostic efficacy (area under the curve, 0.827; 95% confidence interval, 0.752-0.901) in patients with SPNs being suspected lung cancer. Combining CTCs (cut-off value 12 units) with CEA (1.78 ng/ml), the method showed a sensitivity of 77.8% and a specificity of 90% in the diagnosis of NSCLC, especially in the upper lobe, subsolid nodules and nodules ≥8 mm.

conclusionsOur results demonstrated that CTCs are feasible diagnostic biomarkers in patients with SPNs, especially in the upper lobe. Furthermore, CTCs combined with CEA showed higher diagnostic efficacy in the upper lobe, subsolid nodules and nodules ≥8 mm.

Indexed as

Biomarkers, TumorAdultAgedAged, 80 and overCarcinoembryonic AntigenClinical Decision-MakingDisease ManagementDNA Copy Number VariationsFemaleHumansIn Situ Hybridization, FluorescenceLung NeoplasmsMaleMiddle AgedNeoplasm StagingNeoplastic Cells, CirculatingBiomarkers, TumorCarcinoembryonic AntigenCEACirculating tumour cellsLung cancerManagementSolitary pulmonary nodules

Identifiers

PMID32041568
PMCPMC7011271
OpenAlexW3007188424

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.