Evidence map›Paper›PMID 32041482›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2020

Targeting Viral DNA and Promoter Hypermethylation in Salivary Rinses for Recurrent HPV-Positive Oropharyngeal Cancer.

Sarek Shen, Yuki Saito, Shuling Ren, Chao Liu, Theresa Guo, Jesse Qualliotine, Zubair Khan, Sayed Sadat, Joseph A Califano

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. [Latest Research Findings on Health Management Based on Saliva Testing].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Review
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sarek ShenSchool of Medicine, University of California San Diego, La Jolla, California, USA.
Yuki SaitoMoores Cancer Center, University of California San Diego, La Jolla, California, USA.
Shuling RenMoores Cancer Center, University of California San Diego, La Jolla, California, USA.
Chao LiuMoores Cancer Center, University of California San Diego, La Jolla, California, USA.
Theresa GuoDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Jesse QualliotineDepartment of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of California San Diego, San Diego, California, USA.
Zubair KhanDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Sayed SadatMoores Cancer Center, University of California San Diego, La Jolla, California, USA.
Joseph A CalifanoMoores Cancer Center, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USJohns Hopkins University · USXiangya Hospital Central South University · CN

Funding

Epigenetic Biomarker Discovery in HPV Related HNSCCR01DE023347 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CALIFANO, JOSEPH A · 2013 to 2017
$1.9M
Optimizing an assay for high risk HPV DNA in body fluidsUH3CA211396 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CALIFANO, JOSEPH A · 2019 to 2020
$684k
Optimizing an assay for high risk HPV DNA in body fluidsUH2CA211396 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CALIFANO, JOSEPH A · 2017 to 2018
$399k
NCI NIH HHS UH2 CA211396NCI NIH HHS UH3 CA211396NIDCR NIH HHS R01 DE023347
6 · The paper itself

Abstract

objectiveThe incidence and survivorship of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) are increasing. Presence of HPV DNA and epigenetic alterations in salivary rinses are independently associated with clinical prognosis. We evaluated the utility of a combined panel in detecting disease recurrence during surveillance. We also assessed the assay's applicability in screening for HPV+ OPSCC. STUDY

designRetrospective cohort study.

settingTwo tertiary academic hospitals. SUBJECTS AND

methodsForty-nine patients with posttreatment OPSCC were enrolled. Separately, 21 treatment-naive patients and 40 controls were included in the screening analysis. Salivary rinses were obtained from these cohorts and biomarker levels were quantified. Receiver operative characteristic (ROC) curves and multivariate logistic models were used to assess performance of biomarker combinations.

resultsEight patients (16.3%) in the posttreatment cohort developed locoregional recurrence. Recurrence was associated with alcohol use (odds ratio [OR], 6.12; 95% confidence interval [CI], 0.26-3.79) and advanced nodal disease (OR, 2.21; 95% CI, 1.52-3.01). A panel of HPV DNA and methylated

conclusionDetection of high-risk HPV DNA or aberrant hypermethylation in oral rinses is associated with presence and recurrence of OPSCC. Targeting both markers in saliva may have utility in long-term surveillance.

Indexed as

DNA MethylationAgedCohort StudiesDNA, ViralFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalOropharyngeal NeoplasmsPapillomaviridaePromoter Regions, GeneticRetrospective StudiesSalivaSquamous Cell Carcinoma of Head and NeckDNA, ViralepigeneticsHPVhuman papillomavirusoropharyngeal squamous cell carcinomapromoter hypermethylationrecurrencesalivascreening

Identifiers

PMID32041482
PMCPMC7683010
OpenAlexW3006277403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.