Evidence map›Paper›PMID 32041466›Full record

ArticlemAbs

Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires.

Yi-Chun Hsiao, Ying-Jiun J Chen, Leonard D Goldstein, Jia Wu, Zhonghua Lin, Kellen Schneider, Subhra Chaudhuri, Aju Antony, Kanika Bajaj Pahuja, Zora Modrusan and 3 more

Open access · goldAbstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yi-Chun HsiaoDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Ying-Jiun J ChenDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Leonard D GoldsteinDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Jia WuDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Zhonghua LinDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Kellen SchneiderDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Subhra ChaudhuriDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Aju AntonyDepartment of Molecular Biology, SciGenom Labs, Cochin, India.
Kanika Bajaj PahujaDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Zora ModrusanDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Dhaya SeshasayeeDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.
Somasekar SeshagiriDepartment of Molecular Biology, Genentech, South San Francisco, CA, USA.
Isidro HötzelDepartment of Antibody Engineering, Genentech, South San Francisco, CA, USA.ORCID 0000-0001-6910-7840
SciGenom Labs (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibodies from B-cell clonal lineages share sequence and structural properties as well as epitope specificity. Clonally unrelated antibodies can similarly share sequence and specificity properties and are said to be convergent. Convergent antibody responses against several antigens have been described in humans and mice and include different classes of shared sequence features. In particular, some antigens and epitopes can induce convergent responses of clonally unrelated antibodies with restricted heavy (V

Indexed as

Amino Acid SequenceAnimalsAntibody SpecificityEpitopesImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsImmunoglobulin Variable RegionRatsEpitopesImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsImmunoglobulin Variable RegionB cell lineagesbinningconvergencenext-Gen SequencingNGSredundancy

Identifiers

PMID32041466
PMCPMC7039645
OpenAlexW3006182401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.