Evidence map›Paper›PMID 32041353›Full record

ArticleCancers2020

Clinical Relevance of Immune Checkpoints on Circulating Tumor Cells in Breast Cancer.

Maria A Papadaki, Anastasios V Koutsopoulos, Panormitis G Tsoulfas, Eleni Lagoudaki, Despoina Aggouraki, Alexia Monastirioti, Chara Koutoulaki, Christina A Apostolopoulou, Aikaterini C Merodoulaki, Chara Papadaki and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Towards liquid biopsy-based analysis of antitumour immunity.Nature reviews. Clinical oncology · 2026
    Review
  5. Article
  6. Article
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  13. Liquid Biopsy in the Clinical Management of Cancers.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Maria A PapadakiLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Anastasios V KoutsopoulosDepartment of Pathology, University General Hospital of Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Panormitis G TsoulfasLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Eleni LagoudakiDepartment of Pathology, University General Hospital of Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Despoina AggourakiLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Alexia MonastiriotiLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Chara KoutoulakiLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Christina A ApostolopoulouLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Aikaterini C MerodoulakiLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Chara PapadakiLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Dimitrios MavroudisLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
Sofia AgelakiLaboratory of Translational Oncology, School of Medicine, University of Crete, Heraklion, Vassilika Vouton, 71110 Crete, Greece.
University of Crete · GRUniversity Hospital of Heraklion · GR

Funding

Anticancer Research Support Association (ARSA), Heraklion, Greece N.3846/2010Hellenic Society of Medical Oncology Research_funding_2017
6 · The paper itself

Abstract

The role of CD47 and PD-L1 expression on circulating tumor cells (CTCs) remains unclear, and it is currently unknown whether their distribution varies between the blood and tumor tissue in breast cancer (BC). In this study, CD47 and PD-L1 expression was investigated a) on peripheral blood mononuclear cell (PBMC) cytospins from early (

Indexed as

breast cancerCD47CTCsimmune checkpointsimmune escapeimmune responseliquid biopsyPBMCsPD-L1TILs

Identifiers

PMID32041353
PMCPMC7072621
OpenAlexW3005397571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.