Evidence map›Paper›PMID 32041234›Full record

ArticleJournal of clinical medicine2020

Combined Brain-Heart Magnetic Resonance Imaging in Autoimmune Rheumatic Disease Patients with Cardiac Symptoms: Hypothesis Generating Insights from a Cross-sectional Study.

George Markousis-Mavrogenis, Dimos D Mitsikostas, Loukia Koutsogeorgopoulou, Theodoros Dimitroulas, Gikas Katsifis, Panayiotis Argyriou, Dimitrios Apostolou, Stella Velitsista, Vasiliki Vartela, Dionysia Manolopoulou and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

George Markousis-MavrogenisOnassis Cardiac Surgery Center, 17674 Athens, Greece.
Dimos D MitsikostasFirst Neurology Department, National and Kapodistrian University of Athens, 10679 Athens, Greece.
Loukia KoutsogeorgopoulouDepartment of Pathophysiology, Laikon Hospital, 11527 Athens, Greece.
Theodoros DimitroulasDepartment of Rheumatology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Gikas KatsifisRheumatology Department, Naval Hospital, 11521 Athens, Greece.ORCID 0000-0002-3214-7416
Panayiotis ArgyriouMRI Unit, Mediterraneo Hospital, 16675 Athens, Greece.
Dimitrios ApostolouMRI Unit, Mediterraneo Hospital, 16675 Athens, Greece.
Stella VelitsistaMRI Unit, Mediterraneo Hospital, 16675 Athens, Greece.
Vasiliki VartelaOnassis Cardiac Surgery Center, 17674 Athens, Greece.
Dionysia ManolopoulouOnassis Cardiac Surgery Center, 17674 Athens, Greece.
Maria G TektonidouFirst Department of Propaedeutic and Internal medicine, Laikon Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Genovefa KolovouOnassis Cardiac Surgery Center, 17674 Athens, Greece.
George D KitasArthritis Research UK Epidemiology Unit, Manchester University, Manchester M13 9PT, UK.
Petros P SfikakisFirst Department of Propaedeutic and Internal medicine, Laikon Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Sophie I MavrogeniOnassis Cardiac Surgery Center, 17674 Athens, Greece.
Onassis Cardiac Surgery Center · GRNational and Kapodistrian University of Athens · GRAristotle University of Thessaloniki · GRAthens Naval & Veterans Hospital · GRLaiko General Hospital of Athens · GRUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutoimmune rheumatic diseases (ARDs) may affect both the heart and the brain. However, little is known about the interaction between these organs in ARD patients. We asked whether brain lesions are more frequent in ARD patients with cardiac symptoms compared with non-ARD patients with cardiovascular disease (CVD).

methods57 ARD patients with mean age of 48 ± 13 years presenting with shortness of breath, chest pain, and/or palpitations, and 30 age-matched disease-controls with non-autoimmune CVD, were evaluated using combined brain-heart magnetic resonance imaging (MRI) in a 1.5T system.

results52 (91%) ARD patients and 16 (53%) controls had white matter hyperintensities (

conclusionsSubclinical brain involvement was highly prevalent in this cohort of ARD patients and was mostly independent of the severity of cardiac involvement. However, further research is required to determine the clinical relevance of these findings.

Indexed as

brain–heart interactionbrain lesioncardiovascular diseasecognitive dysfunctionneuro-psychiatric symptomsvasculitiswhite matter hyperintensity

Identifiers

PMID32041234
PMCPMC7074384
OpenAlexW3004992563

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.