Evidence map›Paper›PMID 32041131›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis of Functionalized Cannabilactones.

Yingpeng Liu, Thanh C Ho, Mohammed Baradwan, Maria Pascual Lopez-Alberca, Christos Iliopoulos-Tsoutsouvas, Spyros P Nikas, Alexandros Makriyannis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yingpeng LiuCenter for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Thanh C HoCenter for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0001-6880-7570
Mohammed BaradwanCenter for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Maria Pascual Lopez-AlbercaCenter for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.
Christos Iliopoulos-TsoutsouvasCenter for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0003-3750-431X
Spyros P NikasCenter for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0001-5052-5292
Alexandros MakriyannisCenter for Drug Discovery and Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.

Funding

New Modalities for the Treatment of Pain and Drug Abuse-Biochemical CoreP01DA041307 · NIDA · UNIVERSITY OF ARIZONA · PI PORRECA, FRANK · 2017 to 2021
$3.0M
NIDA NIH HHS DA009158; DA045020; DA041307-01
6 · The paper itself

Abstract

A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions.

Indexed as

CannabinoidsChromones3-(1,1-dimethyl-heptyl)-1-9-dihydroxy-benzo(c)chromen-6-one3-(1,1-dimethyl-heptyl)-1-hydroxy-9-methoxy-benzo(c)chromen-6-oneCannabinoidsChromonescannabilactonescannabinoidsCB2 selective ligandsSuzuki cross-coupling

Identifiers

PMID32041131
PMCPMC7037859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.