Evidence map›Paper›PMID 32040835›Full record

ArticleMolecular neurobiology2020

MicroRNA Regulatory Network as Biomarkers of Late Seizure in Patients with Spontaneous Intracerebral Hemorrhage.

Ifeanyi Iwuchukwu, Doan Nguyen, Michelle Beavers, Vi Tran, Wale Sulaiman, Erin Fannin, Lindsay Lasseigne, Eugene Ramsay, Jason Wilson, Nicolas G Bazan

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Role of LMO7 in cancer (Review).Oncology reports · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Seizures and epilepsy in patients with ischaemic stroke.Neurological research and practice · 2021
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ifeanyi IwuchukwuNeurocritical Care and Neurology, University of Queensland, Ochsner Clinical School, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA, 70121, USA. iiwuch@lsuhsc.edu.
Doan NguyenInstitute of Translational Research, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA, 70121, USA.
Michelle BeaversInstitute of Translational Research, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA, 70121, USA.
Vi TranInstitute of Translational Research, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA, 70121, USA.
Wale SulaimanNeurosurgery, Ochsner Neuroscience Institute, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA, 70121, USA.
Erin FanninDepartment of Neurosurgery, Louisiana State University Health New Orleans, School of Medicine, 2020 Gravier Street, 7th Floor, New Orleans, LA, 70112, USA.
Lindsay LasseigneDepartment of Neurosurgery, Louisiana State University Health New Orleans, School of Medicine, 2020 Gravier Street, 7th Floor, New Orleans, LA, 70112, USA.
Eugene RamsayNeurocritical Care and Neurology, University of Queensland, Ochsner Clinical School, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA, 70121, USA.
Jason WilsonDepartment of Neurosurgery, Louisiana State University Health New Orleans, School of Medicine, 2020 Gravier Street, 7th Floor, New Orleans, LA, 70112, USA.
Nicolas G BazanNeuroscience Center of Excellence, Louisiana State University Health New Orleans, School of Medicine, 2020 Gravier Street, 8th Floor, New Orleans, LA, 70112, USA.
Ochsner Medical Center · USLouisiana State University Health Sciences Center New Orleans · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 15% of patients experience seizures after spontaneous intracerebral hemorrhage (ICH). The pathogenesis of seizures post-ICH is not well-known; however, iron deposition-related neuronal injury following hemoglobin breakdown may contribute. Profiling known miRNAs to identify biomarkers for post-ICH late seizures, we found 64 differentially expressed miRNA: 32 upregulated and 32 downregulated in seizure vs. non-seizure. Functional classification of upregulated miRNA for KEGG pathways and biological processes identified enrichment for cell cycle, protein modifications, and FoxO neurotrophin signaling pathways. No significant enrichment was found for downregulated miRNA. Molecular functions Gene Ontology (GO) terms enriched for upregulated miRNA are numerous, while downregulated miRNAs were associated with ion channel activity. RT-PCR confirmed two miRNAs, 4317 and 4325, were differentially expressed in patients who developed seizures at 1 year. MiR-4317 regulates SLC38A1, a glutamine-glutamate transporter. Integrated miRNA-mRNA network analysis identified COMMD6, APOBEC2, and RASSF6-involved in NF-kB regulation. Two miRNAs (miR-4317 and 4325) differentiated post-ICH late seizures vs. non-seizures at 1 year. The results suggest functional and miRNA-mRNA networks as potential biomarkers for post-ICH late seizures.

Indexed as

Gene Regulatory NetworksAdultAgedBiomarkersCerebral HemorrhageFemaleGene Expression ProfilingGene OntologyHumansMaleMicroRNAsMiddle AgedRacial GroupsReal-Time Polymerase Chain ReactionSeizuresSubtraction TechniqueBiomarkersMicroRNAsCirculating miRNAIntracerebral hemorrhageSeizureStroke

Identifiers

PMID32040835
OpenAlexW3005121626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.