SynthesisPediatric nephrology (Berlin, Germany)2020
Association of postoperative fluid overload with adverse outcomes after congenital heart surgery: a systematic review and dose-response meta-analysis.
Synthesis in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A meta-analysis of the incidence rate of postoperative acute kidney injury in patients with congenital heart disease.BMC nephrology · 2020Pooled it
- SBUF-SMUF: On the path to the optimum hemofiltration technique in pediatric cardiopulmonary bypass: A randomized clinical trial.The journal of extra-corporeal technology · 2026Trial
- The incidence and risk factors associated with severe acute kidney injury and operative mortality in neonates following cardiac surgery: a single-center experience.Pediatric nephrology (Berlin, Germany) · 2026Article
- A predictive model for prudent albumin priming in cardiopulmonary bypass circuits.The journal of extra-corporeal technology · 2026Article
- Fluid balance during PICU stay in children after cardiac surgery with cardiopulmonary bypass.European journal of pediatrics · 2026Article
- Development and external validation of an interpretable machine learning model for predicting prolonged postoperative ICU length of stay in coronary artery bypass grafting patients using MIMIC-IV 3.1 and eICU-CRD 2.0.BMC medical informatics and decision making · 2026Article
- Feasibility, reproducibility, clinical value of the VExUS score after pediatric cardiac surgery and main differences from adults' perspective.European journal of pediatrics · 2026Observational
- Contrastive Transformer-Driven Discovery of Temporal Hemodynamic Subphenotypes in Cardiac Surgery Patients.medRxiv : the preprint server for health sciences · 2026Article
- Early Prediction of Postoperative Peritoneal Dialysis Using Lung Ultrasound Scoring in Neonates After Cardiopulmonary Bypass.Journal of cardiovascular development and disease · 2026Article
- The physiologic power of fluid circulation and implications for fluid therapy.Frontiers in veterinary science · 2026Review
- Fluid restriction after pediatric cardiac surgery is independently associated With shorter mechanical ventilation: a retrospective cohort study With adjustment for cardiopulmonary bypass time.Frontiers in pediatrics · 2026Article
- Syndecan-1 as a Biomarker for Fluid Overload After High-Risk Pediatric Cardiac Surgery: A Pilot Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Observational
- Fluid Overload and AKI After the Norwood Operation: The Correlation and Characterization of Routine Clinical Markers.Pediatric cardiology · 2024Article
- An evaluation of the outcomes associated with peritoneal catheter use in neonates undergoing cardiac surgery: A multicenter study.JTCVS open · 2024Article
- Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Article
- Fluid Overload in Pediatric Univentricular Patients Undergoing Fontan Completion.Journal of cardiovascular development and disease · 2023Article
- Fluid balance in pediatric critically ill patients (with and without kidney dysfunction).Current opinion in critical care · 2022Review
- Lung Ultrasound versus Chest X-Ray for the Detection of Fluid Overload in Critically Ill Children: A Systematic Review.Journal of pediatric intensive care · 2022Review
- Fluid overload and mortality in critically ill patients with severe heart failure and cardiogenic shock-An observational cohort study.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric cardiac surgery is commonly associated with acute kidney injury (AKI) and significant fluid retention, which complicate postoperative management and lead to increased rates of morbidity. This meta-analysis aimed to accumulate current literature evidence and evaluate the correlation of fluid overload degree with adverse outcome in patients undergoing congenital heart surgery.
methodsMedline, Scopus, CENTRAL, Clinicaltrials.gov, and Google Scholar were systematically searched from inception. All studies reporting the effects of fluid overload on postoperative clinical outcomes were selected. A dose-response meta-analytic method using restricted cubic splines was implemented in R-3.6.1.
resultsTwelve studies were included, with a total of 3111 pediatric patients. Qualitative synthesis indicated that fluid overload was linked to significantly higher risk of mortality, AKI, prolonged hospital, and intensive care unit (ICU) stay, as well as with increased duration of mechanical ventilation, inotrope need, and infection rate. Meta-analysis demonstrated a linear correlation between fluid overload and the risk of mortality (χ
conclusionsThe present meta-analysis supports that postoperative fluid overload is significantly linked to elevated risk of prolonged hospital stay, AKI development, and mortality in pediatric patients undergoing cardiac surgery. These findings warrant replication by future prospective studies, which should define the optimal cutoff values and assess the effectiveness of therapeutic strategies to limit fluid overload in the postoperative setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.