ArticleJournal of the National Cancer Institute2020
Young-Onset Colon Cancer and Recurrence Risk by Gene Expression.
Article in Journal of the National Cancer Institute, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- LncRNA ELFN1-AS1 promotes colon cancer occurrence and progression by regulating the miR-191-5p/ZBTB34 axis.Translational cancer research · 2026Article
- Microbiome of Young and Later-Onset Colorectal Cancer.The Surgical clinics of North America · 2025Review
- Article
- Comparing Clinicopathological and Immunohistochemical Features of Colorectal Carcinoma between Young and Old Age Groups.Diagnostics (Basel, Switzerland) · 2024Article
- Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment.NPJ precision oncology · 2023Article
- Trifluridine/Tipiracil and Regorafenib in Patients with Metastatic Colorectal Cancer: A Retrospective Study at a Tertiary Oncology Center.The oncologist · 2021Article
- The establishment of a hub differential gene model to predict prognosis in stage II and III right- and left-sided colon cancer patients.Annals of translational medicine · 2021Article
- Dysbiosis of human gut microbiome in young-onset colorectal cancer.Nature communications · 2021Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The incidence and mortality from colorectal cancer in younger adults (younger than 55 years) is increasing. We reviewed the complete database of a gene-expression test, Oncotype DX Colon Recurrence Score test, to determine age-related differences in recurrence score (RS) and single-gene results (7 cancer-related of the 12-gene assay). We included 20 478 stage II and III A and B colon cancer patients submitted to Genomic Health. RS results were grouped by low-, intermediate-, and high-risk groups. Single-gene scores were described using median and interquartile range. Of all patients 72.5% and 72.6% of those younger than 40 years had low-risk RS. Comparing older with younger patients, RS or single-gene expression did not differ by age group or stage. Young-onset colon cancer does not differ by expression of the RS component genes. Most patients with stage II and III colon cancer have low-risk disease as measured by the 12-gene assay, regardless of age.
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