ArticleAIDS (London, England)2020
Mortality and causes of death in people living with HIV in the era of combination antiretroviral therapy compared with the general population in Japan.
Article in AIDS (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Excess mortality attributable to AIDS among people living with HIV in high-income countries: a systematic review and meta-analysis.Journal of the International AIDS Society · 2024Pooled it
- A Systematic Review of Risk Factors for Suicide Among Persons Living with HIV (1996-2020).AIDS and behavior · 2022Pooled it
- Trial
- Development of a mortality risk prediction model for patients on antiretroviral therapy at Felege Hiwot Comprehensive Specialized Hospital: a retrospective cohort study.Scientific reports · 2026Article
- Causes of death in people living with human immunodeficiency virus in Türkiye: a multicentre retrospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- The shifting burden of mortality among men with HIV in Japan between 2007 and 2024: a single-center retrospective cohort study.BMC infectious diseases · 2025Article
- Circulating Biomarker Panorama in HIV-Associated Lymphoma: A Bridge from Early Risk Warning to Prognostic Stratification.Biomolecules · 2025Review
- Current State of AIDS-Related Malignant Lymphoma.Viruses · 2025Review
- Predictors of survival among older adults with HIV in Uganda's AIDS support organization centers of excellence (1987-2023): a retrospective longitudinal study.AIDS research and therapy · 2025Article
- Early Detection of Cancer and Precancerous Lesions in Persons With HIV Through a Comprehensive Cancer Screening Protocol.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Epidemiologic characteristics of people living with human immunodeficiency virus in South Korea: a nationwide cohort study.Scientific reports · 2024Article
- Mortality and comorbidities in a Nationwide cohort of HIV-infected adults: comparison to a matched non-HIV adults' cohort, France, 2006-18.European journal of public health · 2024Article
- Incidence of Colon Cancer Among Medicaid Beneficiaries With or Without Human Immunodeficiency Virus Under Comparable Colorectal Cancer Screening Patterns.Open forum infectious diseases · 2024Article
- Coronary artery stenosis in Japanese people living with HIV-1 with or without haemophilia.Global health & medicine · 2024Article
- Survival and mortality profile among people living with HIV in a cohort in the Northeastern region of Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Risk factors for suicide among veterans living with and without HIV: a nested case-control study.AIDS and behavior · 2024Article
- Article
- Efficacy of Antibodies Targeting TfR1 in Xenograft Mouse Models of AIDS-Related Non-Hodgkin Lymphoma.Cancers · 2023Article
- CT imaging of HIV-associated pulmonary disorders in COVID-19 pandemic.Clinical imaging · 2023Review
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the mortality and causes of death in people living with HIV (PLHIV) in Japan.
designA prospective cohort study at AIDS Clinical Center, Tokyo, which treats approximately 10% of PLHIV in care in Japan.
methodsEither PLHIV who visited our center for the first time between January 2005 and December 2014 or PLHIV who started their regular visit before January 2005 and visited us between January and March 2005 were included and followed by the end of 2016. Causes of death were defined according to the CoDe protocol.
resultsTwo thousand, seven hundred and ninety-seven PLHIV were analysed with total of 18 858 person-years of follow-up, which constitutes 14% of the estimated number of PLHIV in care in Japan. One hundred and sixty-five (5.9%) PLHIV died with all-cause mortality rate of 8.75 per 1000 person-years. All-cause mortality rate for PLHIV in care in Japan was estimated to be 8.75 per 1000 person-years (95% CI 5.53-12.0). Among causes of death, AIDS-defining illnesses accounted for 39% and malignancy contributed to 47%. Standardized mortality ratio (SMR) for all-cause mortality, malignancy-related mortality, and suicide were 5.96 (95% CI 5.05-6.87), 7.76 (95% CI 6.02-9.51), and 3.24 (95% CI 1.54-4.94), respectively. Even among the patients who were diagnosed early or without history of AIDS, SMR was four times higher than the general population.
conclusionMortality of PLHIV, even among those with early diagnosis, is substantially higher than that of the general population in Japan, highlighting the importance of further efforts towards prevention, early diagnosis and prompt treatment initiation.
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