Evidence map›Paper›PMID 32039854›Full record

ArticleJournal of Alzheimer's disease : JAD2020

Late-Life Physical and Cognitive Activities Independently Contribute to Brain and Cognitive Resilience.

Kaitlin B Casaletto, Miguel Arce Rentería, Judy Pa, Sarah E Tom, Amal Harrati, Nicole M Armstrong, K Bharat Rajan, Dan Mungas, Samantha Walters, Joel Kramer and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Selected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  6. Cognitive reserve against vascular contributions to cognitive impairment and dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Kaitlin B CasalettoDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Miguel Arce RenteríaDepartment of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Judy PaDepartment of Neurology, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Sarah E TomDepartment of Neurology, Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Amal HarratiDepartment of Primary Care and Population Health, Center for Population Health Sciences, Stanford University, Stanford, CA, USA.
Nicole M ArmstrongLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
K Bharat RajanUniversity of California, Davis, Davis, CA, USA.
Dan MungasUniversity of California, Davis, Davis, CA, USA.
Samantha WaltersDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Joel KramerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Laura B ZahodneDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Columbia University · USUniversity of California, Davis · USUniversity of California, San Francisco · USNational Institute on Aging · USStanford University · USUniversity Memory and Aging Center · USUniversity of Michigan–Ann Arbor · USUniversity of Southern California · US

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI OLICHNEY, JOHN M · 1991 to 2020
$28.3M
Preserving Cognitive Resilience: A Biracial Parent-Offspring Study (18-4674) - Feasibility StudyR01AG058679 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI EVANS, DENIS A, RAJAN, KUMAR B. · 2019 to 2024
$13.8M
Brain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative DiseaseRF1AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2020 to 2021
$5.3M
Heterogeneity of Mild Cognitive Impairment(MCI)R01AG021028 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 2003 to 2014
$4.6M
ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYR01AG010220 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI MUNGAS, DAN M. · 1992 to 2012
$4.5M
Brain pathologies, reserve and cognition in aging and dementiaRF1AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MUNGAS, DAN M. · 2015 to 2015
$3.8M
Gender and APOE4 Effects on Brain Morphometry, Cognition, and Clinical Progression to Alzheimer's Disease.RF1AG054617 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PA, JUDY · 2017 to 2017
$3.7M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Effects of physical activity on brain function and network connectivity in MCIR01AG046928 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2015 to 2020
$3.2M
NIA NIH HHS K01 AG050723NIA NIH HHS K23 AG058752NIA NIH HHS L30 AG057123NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG010220NIA NIH HHS R01 AG021028NIA NIH HHS R01 AG031252NIA NIH HHS R01 AG031563NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG046928NIA NIH HHS R01 AG047827NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG051635NIA NIH HHS R01 AG058679NIA NIH HHS R13 AG030995NIA NIH HHS RF1 AG031563NIA NIH HHS RF1 AG032289NIA NIH HHS RF1 AG054617NIA NIH HHS RF1 AG057532
6 · The paper itself

Abstract

backgroundActive lifestyles are related to better cognitive aging outcomes, yet the unique role of different types of activity are unknown.

objectiveTo examine the independent contributions of physical (PA) versus cognitive (CA) leisure activities to brain and cognitive aging.

methodsIndependent samples of non-demented older adults from University of California, San Francisco Hillblom Aging Network (UCSF; n = 344 typically aging) and University of California, Davis Diversity cohort (UCD; n = 485 normal to MCI) completed: 1) self-reported engagement in current PA and CA (UCSF: Physical Activity Scale for the Elderly and Cognitive Activity Scale; UCD: Life Experiences Assessment Form); 2) neuropsychological batteries; and 3) neuroimaging total gray matter volume, white matter hyperintensities, and/or global fractional anisotropy. PA and CA were simultaneously entered into multivariable linear regression models, adjusting for demographic characteristics and functional impairment severity.

resultsBrain outcomes: In UCSF, only PA was positively associated with gray matter volume and attenuated the relationship between age and fractional anisotropy. In UCD, only CA was associated with less white matter hyperintensities and attenuated the relationship between age and gray matter volume. Cognitive outcomes: In both cohorts, greater CA, but not PA, related to better cognition, independent of age and brain structure. In UCSF, CA attenuated the relationship between fractional anisotropy and cognition. In UCD, PA attenuated the association between white matter hyperintensities and cognition.

conclusionsAlthough their specificity was not easily teased apart, both PA and CA are clearly related to better brain and cognitive resilience markers across cohorts with differing educational, racial, and disease statuses. PA and CA may independently contribute to converging neuroprotective pathways for brain and cognitive aging.

Indexed as

Life StyleResilience, PsychologicalAgedAnisotropyCognitionCognitive DysfunctionCohort StudiesCross-Sectional StudiesDiffusion Tensor ImagingExerciseFemaleGray MatterHealthy AgingHumansMagnetic Resonance ImagingMaleBrain agingcognitive agingexercisemental stimulationreserve

Identifiers

PMID32039854
PMCPMC7233450
OpenAlexW3005374648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.