ArticleJournal of Alzheimer's disease : JAD2020
Longer Duration of Hypertension and MRI Microvascular Brain Alterations Are Associated with Lower Hippocampal Volumes in Older Individuals with Hypertension.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Incidence of cognitive impairment post first stroke: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Sex-specific differences in clinical characteristics and organ damage in Hypertensive Urgencies.Internal and emergency medicine · 2026Observational
- Association Between Carotid Atherosclerosis and Post-Stroke Cognitive Impairment in Patients With Mild Ischemic Stroke: A Prospective Cohort Study.CNS neuroscience & therapeutics · 2026Article
- Angiotensin II-mediated hippocampal hypoperfusion and vascular dysfunction contribute to vascular cognitive impairment in aged hypertensive rats.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Alterations in regional homogeneity and functional connectivity associated with cognitive impairment in patients with hypertension: a resting-state functional magnetic resonance imaging study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Relationship between arterial stiffness and cognitive function in outpatients with dementia and mild cognitive impairment compared with community residents without dementia.Journal of geriatric cardiology : JGC · 2022Article
- Relationship Between Hypertension and Cognitive Function in an Elderly Population: A Population-Based Study in Rural Northern China.Frontiers in neurology · 2022Article
- Hypertension Status Moderated the Relationship between the Hippocampal Subregion of the Left GC-ML-DG and Cognitive Performance in Subjective Cognitive Decline.Disease markers · 2022Article
- Associations of changes in late-life blood pressure with cognitive impairment among older population in China.BMC geriatrics · 2021Article
- Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment.Biomedicines · 2021Review
- Leukoaraiosis and Gray Matter Volume Alteration in Older Adults: The PROOF Study.Frontiers in neuroscience · 2021Article
- White Matter Fractional Anisotropy Is a Superior Predictor for Cognitive Impairment Than Brain Volumes in Older Adults With Confluent White Matter Hyperintensities.Frontiers in psychiatry · 2021Article
- Associations Between Brain Volumes and Cognitive Tests with Hypertensive Burden in UK Biobank.Journal of Alzheimer's disease : JAD · 2021Article
- Increase in Right Temporal Cortex Thickness Is Related to Decline of Overall Cognitive Function in Patients With Hypertension.Frontiers in cardiovascular medicine · 2021Article
- Evolution of Brain Morphology in Spontaneously Hypertensive and Wistar-Kyoto Rats From Early Adulthood to Aging: A Longitudinal Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2021Article
- Effect of Combined Antihypertensive and Lipid-Lowering Therapies on Cognitive Function: A New Treatment Strategy?Cardiology research and practice · 2020Review
- Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period.Dementia and geriatric cognitive disorders extraArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHippocampal atrophy is associated with cognitive decline. Determining the clinical features associated with hippocampal volume (HV)/atrophy may help in tailoring preventive strategies.
objectiveThis study was aimed to investigate the association between HV (at visit 2) and vascular status (both at visit 1 and visit 2) in a cohort of individuals aged 60+ with hypertension and without overt cognitive impairment at visit 1 (visit 1 and visit 2 were separated by approximately 8 years).
methodsHippocampal volume was estimated in brain MRIs as HV both clinically with the Scheltens' Medial Temporal Atrophy score, and automatically with the Free Surfer Software application. A detailed medical history, somatometric measurements, cognitive tests, leukoaraiosis severity (Fazekas score), vascular parameters including pulse wave velocity, central blood pressure, and carotid artery plaques, as well as several biochemical parameters were also measured.
results113 hypertensive patients, 47% male, aged 75.1±5.6 years, participated in both visit 1 and visit 2 of the ADELAHYDE study. Age (β= -0.30) and hypertension duration (β= -0.20) at visit 1 were independently associated with smaller HV at visit 2 (p < 0.05 for all). In addition to these variables, low body mass index (β= 0.18), high MRI Fazekas score (β= -0.20), and low Gröber-Buschke total recall (β= 0.27) were associated with smaller HV at visit 2 (p < 0.05 for all).
conclusionIn a cohort of older individuals without cognitive impairment at baseline, we described several factors associated with lower HV, of which hypertension duration can potentially be modified.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.