ArticleJournal of Alzheimer's disease : JAD2020
Alcohol Consumption, Brain Amyloid-β Deposition, and Brain Structural Integrity Among Older Adults Free of Dementia.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The role of APOE ε4 in modulating the relationship between non-genetic risk factors and dementia: a system review and meta-analysis.Journal of neurology · 2025Pooled it
- Higher amyloid deposition and lower white matter volume in cognitively healthy seniors exceeding French alcohol recommendations.EBioMedicine · 2026Article
- Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study.The Journal of clinical investigation · 2026Article
- Alcohol-Induced Dysregulation of Hydrogen Sulfide Signaling in Alzheimer's Disease-International journal of molecular sciences · 2026Review
- Associations of moderate alcohol intake with cerebrospinal fluid biomarkers of Alzheimer's disease: data from the ALBION study.European journal of nutrition · 2025Article
- Impact of alcohol use disorder on cognition in correlation with aging: a community-based retrospective cohort study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Longitudinal alcohol-related brain changes in older adults: The Sydney Memory and Ageing Study.Addiction biology · 2024Article
- Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline.Neurobiology of stress · 2024Article
- Alcohol Use Disorder and Dementia: A Review.Alcohol research : current reviews · 2024Review
- Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol.Alcohol (Fayetteville, N.Y.) · 2023Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundLight to moderate alcohol consumption has been variably associated with lower or higher risk of dementia, but effects on Alzheimer's disease pathology are less clear.
objectiveWe determined whether late-life alcohol consumption was associated with Alzheimer's disease pathology among older adults.
methodsWe assessed the associations of alcohol consumption self-reported in 2000-2002 with brain amyloid-β deposition on PET scans, and white matter lesion and hippocampal volume on MRIs measured 7-9 years later in 189 participants of the Ginkgo Evaluation of Memory Study (age 75-87 years at baseline) who were free of clinical dementia, using multivariable-adjusted and inverse probability-weighted robust linear regression models.
resultsAlcohol consumption was not statistically significantly associated with amyloid-β deposition (standardized uptake value ratio difference per drink: -0.013 [95% CI: -0.027, 0.002]). Both non-drinkers and participants consuming ≥1 drink(s)/week had higher white matter lesion volume (% intracranial volume) than did the reference group of those consuming <1 drink/week (differences: 0.25 % [95% CI: 0.01, 0.50]; 0.26 % [95% CI: 0.02, 0.50]). The association of alcohol consumption and hippocampal volume was modified by age (p = 0.02). Among participants younger than 77 years, participants consuming 1-7 drinks/week had larger hippocampal volume compared with participants consuming <1 drink/week.
conclusionsAlcohol consumption was not statistically significantly associated with amyloid-β deposition 7-9 years later. Non-drinking and greater alcohol consumption were associated with higher white matter lesion volume compared with drinking <1 drink/week. Moderate drinking was associated with higher hippocampal volume in younger individuals. Given the selective nature of this population and adverse health effects of excessive alcohol consumption, these findings warrant further investigation, but cannot be translated into clinical recommendations.
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