Evidence map›Paper›PMID 32039830›Full record

ArticleAging2020

Single-cell RNA sequencing of immune cells in gastric cancer patients.

Kai Fu, Bingqing Hui, Qian Wang, Chen Lu, Weihong Shi, Zhigang Zhang, Dawei Rong, Betty Zhang, Zhaofeng Tian, Weiwei Tang and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
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  10. Single-cell multi-omics in the study of digestive system cancers.Computational and structural biotechnology journal · 2024
    Review
  11. Review
  12. Review
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  14. Review
  15. Tumor-infiltrating monocytic myeloid-derived suppressor cells contribute to the development of an immunosuppressive tumor microenvironment in gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Kai FuDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Bingqing HuiDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qian WangDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Chen LuDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Weihong ShiJiangsu Research Center for Primary Health Development and General Education, Jiangsu Vocational College of Medicine, Yancheng, China.
Zhigang ZhangDepartment of General Surgery, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Dawei RongDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Betty ZhangMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Zhaofeng TianDepartment of Laboratory Diagnostics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Weiwei TangDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Hongyong CaoDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xuehao WangHepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Transplantation, Chinese Academy of Medical Sciences, Nanjing, China.
Ziyi ChenHepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Transplantation, Chinese Academy of Medical Sciences, Nanjing, China.
Nanjing Medical University · CNJiangsu Province Hospital · CNJiangsu Vocational College of Medicine · CNMcMaster University · CASecond Military Medical University · CNZhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtypes and their heterogeneous transcription factors and depicted their developmental trajectories. In particular, we focused on exhausted CD8

Indexed as

Single-Cell AnalysisAgedAged, 80 and overCase-Control StudiesCD8-Positive T-LymphocytesDown-RegulationFemaleHumansInterferon Regulatory Factor-8Interferon Regulatory FactorsMaleSequence Analysis, RNAStomach NeoplasmsT-Lymphocytes, RegulatoryInterferon Regulatory Factor-8Interferon Regulatory Factorsexhaustedgastric cancerimmunotherapysingle-cell RNA sequencing

Identifiers

PMID32039830
PMCPMC7041746
OpenAlexW3006275477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.