ArticleeLife2020
Ubiquitous macropinocytosis in anthozoans.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026Review
- Building like a Coral-Parallelized, Multiscale Biofabrication.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Effects of Polysaccharide Coating on Cell-Surface Association and Endocytic Uptake of PLGA Nanomicelles in MCF-7 Cells.Pharmaceutics · 2025Article
- Insights on the intracellular trafficking of calcifying medium in a reef-building coral.Communications biology · 2025Article
- Co-option of immune and digestive cellular machinery to support photosymbiosis in amoebocytes of the upside-down jellyfish Cassiopea xamachana.The Journal of experimental biology · 2025Article
- Targeting Wnt-driven metabolic adaptations in cancer: integrating glycolysis, glutaminolysis, IDO1-mediated immune evasion, and therapeutic delivery strategies.Frontiers in cell and developmental biology · 2025Review
- Making cups and rings: the 'stalled-wave' model for macropinocytosis.Biochemical Society transactions · 2024Review
- Cellular Regulation of Macropinocytosis.International journal of molecular sciences · 2024Review
- NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy.ACS applied materials & interfaces · 2024Article
- Mechanical stretch regulates macropinocytosis inMolecular biology of the cell · 2024Article
- Myriad Mapping of nanoscale minerals reveals calcium carbonate hemihydrate in forming nacre and coral biominerals.Nature communications · 2024Article
- Formation and closure of macropinocytic cups in Dictyostelium.Current biology : CB · 2023Article
- Soluble lectin LePin mediates alga recognition to initiate coral-algal endosymbiosis.Nature microbiology · 2023Article
- Coral-algal endosymbiosis characterized using RNAi and single-cell RNA-seq.Nature microbiology · 2023Article
- Investigating calcification-related candidates in a non-symbiotic scleractinian coral, Tubastraea spp.Scientific reports · 2022Article
- Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Distinct fine-scale variations in calcification control revealed by high-resolution 2D boron laser images in the cold-water coralScience advances · 2022Article
- A Rhesus channel in the coral symbiosome membrane suggests a novel mechanism to regulate NHScience advances · 2022Article
- Biomineralization: Integrating mechanism and evolutionary history.Science advances · 2022Review
- Heat stress increases immune cell function in Hexacorallia.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transport of fluids, molecules, nutrients or nanoparticles through coral tissues are poorly documented. Here, we followed the flow of various tracers from the external seawater to within the cells of all tissues in living animals. After entering the general coelenteric cavity, we show that nanoparticles disperse throughout the tissues via the paracellular pathway. Then, the ubiquitous entry gate to within the cells' cytoplasm is macropinocytosis. Most cells form large vesicles of 350-600 nm in diameter at their apical side, continuously internalizing their surrounding medium. Macropinocytosis was confirmed using specific inhibitors of PI3K and actin polymerization. Nanoparticle internalization dynamics is size dependent and differs between tissues. Furthermore, we reveal that macropinocytosis is likely a major endocytic pathway in other anthozoan species. The fact that nearly all cells of an animal are continuously soaking in the environment challenges many aspects of the classical physiology viewpoints acquired from the study of bilaterians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.