ReviewMovement disorders : official journal of the Movement Disorder Society2020
Debugging Adaptive Deep Brain Stimulation for Parkinson's Disease.
Review in Movement disorders : official journal of the Movement Disorder Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adaptive deep brain stimulation for Parkinson's disease: looking back at the past decade on motor outcomes.Journal of neurology · 2023Pooled it
- Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial.Nature medicine · 2024Trial
- Adaptive versus conventional deep brain stimulation for bradykinesia in Parkinson's disease: a comparative effectiveness analysis.Acta neurologica Belgica · 2026Review
- The Distinct Electrophysiological Mechanisms in the Cortico-Striatal Circuit of LID Rats.Biology · 2026Article
- Increased beta-HFO phase-amplitude coupling in the subthalamic nucleus during movement in Parkinson's disease.Neuroimage. Reports · 2026Article
- From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Real-Time ECG Artifact Removal for Adaptive Deep Brain Stimulation: A Comparative Study.Sensors (Basel, Switzerland) · 2026Article
- Excessive daytime sleepiness in parkinsonism is associated with cortical and basal ganglia beta oscillatory activity.Communications biology · 2026Article
- Movement-responsive deep brain stimulation for Parkinson's disease using a remotely optimized neural decoder.Nature biomedical engineering · 2026Article
- Gait analysis for Parkinson's disease using multiscale entropy.Neurodegenerative disease management · 2025Review
- Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease.Science advances · 2025Article
- Deep brain stimulation-induced local evoked potentials outperform spectral features in spatial and clinical STN mapping.Journal of neural engineering · 2025Article
- Will adaptive deep brain stimulation for Parkinson's disease become a real option soon? A Delphi consensus study.NPJ Parkinson's disease · 2025Article
- Local Field Potential Biomarkers of Non-Motor Symptoms in Parkinson's Disease: Insights From the Subthalamic Nucleus in Deep Brain Stimulation.The European journal of neuroscience · 2025Review
- Review
- Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) clinical trial.NPJ Parkinson's disease · 2024Article
- Article
- Generalized sleep decoding with basal ganglia signals in multiple movement disorders.NPJ digital medicine · 2024Article
- Automatic sleep-wake classification and Parkinson's disease recognition using multifeature fusion with support vector machine.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease. In adaptive DBS, stimulation is titrated according to feedback about clinical state and underlying pathophysiology. This contrasts with conventional stimulation, which is fixed and continuous. In acute trials, adaptive stimulation matches the efficacy of conventional stimulation while delivering about half the electrical energy. The latter means potentially fewer side-effects. The next step is to determine the long-term efficacy, efficiency, and side-effect profile of adaptive stimulation, and chronic trials are currently being considered by the medical devices industry. However, there are several different approaches to adaptive DBS, and several possible limitations have been highlighted. Here we review the findings to date to ascertain how and who to stimulate in chronic trials designed to establish the long-term utility of adaptive DBS. © 2020 International Parkinson and Movement Disorder Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.