Evidence map›Paper›PMID 32039364›Full record

ArticleJHEP reports : innovation in hepatology2019

Promoter hypermethylation of the

Fabián Arenas, Isabel Hervías, Elena Sáez, Saida Melero, Jesús Prieto, Albert Parés, Juan F Medina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Potential Theranostic Roles of SLC4 Molecules in Human Diseases.International journal of molecular sciences · 2023
    Review
  4. Sequence of events leading to primary biliary cholangitis.World journal of gastroenterology · 2023
    Review
  5. Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis.Journal of clinical and translational hepatology · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. The current issue of JHEP Reports.JHEP reports : innovation in hepatology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fabián ArenasDivision of Gene Therapy and Hepatology, CIMA, School of Medicine and Clinic University of Navarra, and Ciberehd, Pamplona.
Isabel HervíasDivision of Gene Therapy and Hepatology, CIMA, School of Medicine and Clinic University of Navarra, and Ciberehd, Pamplona.
Elena SáezDivision of Gene Therapy and Hepatology, CIMA, School of Medicine and Clinic University of Navarra, and Ciberehd, Pamplona.
Saida MeleroDivision of Gene Therapy and Hepatology, CIMA, School of Medicine and Clinic University of Navarra, and Ciberehd, Pamplona.
Jesús PrietoDivision of Gene Therapy and Hepatology, CIMA, School of Medicine and Clinic University of Navarra, and Ciberehd, Pamplona.
Albert ParésLiver Unit, Hospital Clinic, IDIBAPS, University of Barcelona, and Ciberehd, Barcelona, Spain.
Juan F MedinaDivision of Gene Therapy and Hepatology, CIMA, School of Medicine and Clinic University of Navarra, and Ciberehd, Pamplona.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsPatients with primary biliary cholangitis (PBC) exhibit reduced

methodsCpG-cytosine methylation rates were interrogated at 1-base pair resolution in upstream and alternate

results

conclusionsDisease-specific hypermethylation of LAY SUMMARY: Primary biliary cholangitis (PBC) is a chronic immune-associated cholestatic liver disease with unclear complex/multifactorial etiopathogenesis affecting mostly middle-aged women. Patients with PBC exhibit reduced expression of the

Indexed as

AE2 chloride/bicarbonate exchangercholestasisDNA methylationepigenetic repressionprimary biliary cholangitis/cirrhosis

Identifiers

PMID32039364
PMCPMC7001545

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.