Evidence map›Paper›PMID 32039224›Full record

ArticleFrontiers in medicine2020

Erythropoietin Derived Peptide Improved Endoplasmic Reticulum Stress and Ischemia-Reperfusion Related Cellular and Renal Injury.

Yufang Zhang, Qian Wang, Aifen Liu, Yuanyuan Wu, Feng Liu, Hui Wang, Tongyu Zhu, Yaping Fan, Bin Yang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. High-mobility group box 1 in acute kidney injury.Frontiers in pharmacology · 2025
    Review
  4. Article
  5. Article
  6. Caffeine and neonatal acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yufang ZhangRenal Group, Basic Medical Research Centre, Medical College of Nantong University, Nantong, China.
Qian WangDepartment of Nephrology, Nantong-Leicester Joint Institute of Kidney Science, Affiliated Hospital of Nantong University, Nantong, China.
Aifen LiuRenal Group, Basic Medical Research Centre, Medical College of Nantong University, Nantong, China.
Yuanyuan WuDepartment of Cardiovascular Sciences, University of Leicester, University Hospitals of Leicester, Leicester, United Kingdom.
Feng LiuDepartment of Nephrology, Nantong-Leicester Joint Institute of Kidney Science, Affiliated Hospital of Nantong University, Nantong, China.
Hui WangDepartment of Nephrology, Nantong-Leicester Joint Institute of Kidney Science, Affiliated Hospital of Nantong University, Nantong, China.
Tongyu ZhuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yaping FanDepartment of Nephrology, Nantong-Leicester Joint Institute of Kidney Science, Affiliated Hospital of Nantong University, Nantong, China.
Bin YangDepartment of Nephrology, Nantong-Leicester Joint Institute of Kidney Science, Affiliated Hospital of Nantong University, Nantong, China.
Nantong University · CNAffiliated Hospital of Nantong University · CNUniversity of Leicester · GBFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia-reperfusion (IR) injury often affects transplant and native kidneys alike. IR injury is one of the main causes of acute kidney injury (AKI) and further associated with the progression of chronic kidney disease. Our previous study revealed the renoprotection of erythropoietin derived cyclic helix-B surface peptide (CHBP) against IR injury. However, the precise role and underlying mechanism of endoplasmic reticulum stress (ERS) in the injury and the renoprotection induced by IR or CHBP, respectively, have not been fully defined. This study using mouse kidney epithelial cells (TCMK-1) revealed that the level of CHOP (a key marker of ERS), PERK, and JNK (regulators of CHOP) was gradually increased by the prolonged time of hydrogen peroxide (H

Indexed as

apoptosisCHOPcyclic helix-B surface peptide (CHBP)endoplasmic reticulum stress (ERS)inflammationischemia-reperfusion injury

Identifiers

PMID32039224
PMCPMC6992600
OpenAlexW3001156188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.