ArticleFrontiers in bioengineering and biotechnology2019
Optimization of the Lipase-Catalyzed Selective Amidation of Phenylglycinol.
Article in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Poly (Ethylene-Alt-Maleic Anhydride) Ionic Modification of Lipase B fromMolecules (Basel, Switzerland) · 2026Article
- A Sustainable Green Enzymatic Method for Amide Bond Formation.Molecules (Basel, Switzerland) · 2023Article
- Microbial Lipases and Their Potential in the Production of Pharmaceutical Building Blocks.International journal of molecular sciences · 2022Review
- The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils?Molecules (Basel, Switzerland) · 2022Review
- Lipase Assisted (Pharmaceuticals (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ceramides and their analogs have a regulatory effect on inflammatory cytokines expression. It was found that a kind of ceramides analog synthesized from phenylglycinol could inhibit the production of cytokine TNF-α. However, two active hydrogen groups are present in the phenylglycinol molecule. It is difficult to control the process without hydroxyl group protection to dominantly produce amide in the traditional chemical synthesis. A selective catalytic the amidation route of phenylglycinol by lipases was investigated in this research. The results indicated that the commercial immobilized lipase Novozym 435 has the best regio-selectivity on the amide group. Based on the experimental results and
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Registered trials
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