ArticleFrontiers in pediatrics2019
Simultaneous Near-Infrared Spectroscopy (NIRS) and Amplitude-Integrated Electroencephalography (aEEG): Dual Use of Brain Monitoring Techniques Improves Our Understanding of Physiology.
Article in Frontiers in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03786497 (Protecting Brains and Saving Futures - the PBSF Protocol), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Protecting Brains and Saving Futures - the PBSF Protocol: a Prospective Multicenter and Observational Study on the Use of Telemedicine for Neurocritical Care in High-risk Newborns in Brazil.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Digital neonatal neurocritical care in Brazil: a retrospective multicentre cohort study of over 11,000 remotely monitored infants.Lancet regional health. Americas · 2025Article
- Impact of persistent pulmonary hypertension on cerebral oxygenation in infants with neonatal encephalopathy.Pediatric research · 2025Article
- Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy.Scientific reports · 2025Article
- Review of measurements and imaging of cytochrome-c-oxidase in humans using near-infrared spectroscopy: an update.Biomedical optics express · 2024Review
- Feasibility of bedside portable MRI in neonates and children during ECLS.Critical care (London, England) · 2023Article
- Multimodal monitoring: practical recommendations (dos and don'ts) in challenging situations and uncertainty.Frontiers in neurology · 2023Review
- Newer indications for neuromonitoring in critically ill neonates.Frontiers in pediatrics · 2023Article
- Optimal neuromonitoring techniques in neonates with hypoxic ischemic encephalopathy.Frontiers in pediatrics · 2023Review
- Utilizing near infra-red spectroscopy to identify physiologic variations during digital retinal imaging in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Observational
- Article
- [Biomarkers and neuromonitoring for prognosis of development after perinatal brain damage].Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde · 2022Review
- Cardiovascular management following hypoxic-ischemic encephalopathy in North America: need for physiologic consideration.Pediatric research · 2021Article
- Causes, Effects and Methods of Monitoring Gas Exchange Disturbances during Equine General Anaesthesia.Animals : an open access journal from MDPI · 2021Review
- Precision Medicine in Neonates: A Tailored Approach to Neonatal Brain Injury.Frontiers in pediatrics · 2021Review
- Best practices for fNIRS publications.Neurophotonics · 2021Article
- Current Status and Future Directions of Neuromonitoring With Emerging Technologies in Neonatal Care.Frontiers in pediatrics · 2021Review
- Potential Relationship between Cerebral Fractional Tissue Oxygen Extraction (FTOE) and the Use of Sedative Agents during the Perioperative Period in Neonates and Infants.Children (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous brain monitoring tools are increasingly being used in the neonatal intensive care unit (NICU) to assess brain function and cerebral oxygenation in neonates at high risk for brain injury. Near infrared spectroscopy (NIRS) is useful in critically ill neonates as a trend monitor to evaluate the balance between tissue oxygen delivery and consumption, providing cerebral and somatic oximetry values, and allowing earlier identification of abnormalities in hemodynamics and cerebral perfusion. Amplitude-integrated electroencephalography (aEEG) is a method for continuous monitoring of cerebral function at the bedside. Simultaneous use of both monitoring modalities may improve the understanding of alterations in hemodynamics and risk of cerebral injury. Several studies have described correlations between aEEG and NIRS monitoring, especially in infants with hypoxic-ischemic encephalopathy (HIE), but few describe the combined use of both monitoring techniques in a wider range of clinical scenarios. We review the use of NIRS and aEEG in neonates and describe four cases where abnormal NIRS values were immediately followed by changes in brain activity as seen on aEEG allowing the impact of a hemodynamic disturbance on the brain to be correlated with the changes in the aEEG background pattern. These four clinical scenarios demonstrate how simultaneous neuromonitoring with aEEG and NIRS provides important clinical information. We speculate that routine use of these combined monitoring modalities may become the future standard for neonatal neuromonitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.