ArticleTranslational andrology and urology2019
Association between polychlorinated biphenyl 153 exposure and serum testosterone levels: analysis of the National Health and Nutrition Examination Survey.
Article in Translational andrology and urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Polychlorinated biphenyl 153 alters the intestinal epithelial cell transcriptome.Biomedical reports · 2026Article
- Article
- Associations of PFAS and OH-PCBs with risk of multiple sclerosis onset and disability worsening.Nature communications · 2025Article
- Association between Fish Intake and Serum Testosterone Levels in Older Males: The Hitachi Health Study II.Current developments in nutrition · 2024Article
- Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction.Antioxidants (Basel, Switzerland) · 2021Review
- Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011-2016.Translational andrology and urology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo examine the effects of environmental polychlorinated biphenyls (PCBs) 153 exposure, an industrial plasticizer, on serum testosterone levels.
methodsUsing data collected from the 1999-2000 and 2001-2002 National Health and Nutrition Examination Survey (NHANES), we analyzed serum total testosterone and PCB153 levels, demographic data and comorbidities for men aged 18 years and older. Univariate and multivariate linear regression analysis was used to evaluate the association between total testosterone and serum PCB153.
resultsFive hundred and fifty-seven men met inclusion criteria. Median age was 45.7 [33.4-60.4] years old while median serum total testosterone and PCB153 levels were 479 [352.5-607] ng/dL and 0.20 [0.11-0.39] ng/g, respectively. Increasing age, higher body mass index (BMI), higher levels of serum PCB153, lower levels of activity and a history of diabetes mellitus and coronary heart disease were associated with decreasing serum testosterone levels on univariate linear regression. On multivariate linear regression, increasing age (estimate -6.29 ng/dL per year of life, P<0.001) and BMI (estimate -7.08 ng/dL per unit BMI, P<0.001) were associated with declining serum testosterone levels. While serum PCB153 levels were found to be negatively correlated with serum testosterone levels on univariate analysis (estimate -179.67, P<0.001), this association was not significant on the multivariable model (estimate -12.83, P=0.673).
conclusionsIn this population-based analysis, we report an association between a decrease in serum testosterone with increasing serum levels of PCB153. Identifying environmental factors for etiology of low testosterone and mechanisms for causation will be important to aid in strategies to increase testosterone naturally in men.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.