ArticleTranslational andrology and urology2019
Mild experimental increase in testis and epididymis temperature in men: effects on sperm morphology according to spermatogenesis stages.
Article in Translational andrology and urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Garment fit, scrotal thermoregulation, and male fertility outcomes: a narrative review.Translational andrology and urology · 2026Review
- The fertility of a sub-population of stallions is negatively affected by ambient climatic conditions, mediated through DNA damage.International journal of biometeorology · 2026Article
- Functional rescue and AI analysis of a human inactivating GPCR mutation using a small molecule.EMBO molecular medicine · 2026Article
- Photobiomodulation is more effective than long-term scrotal hyperthermia in improving testis tissue and spermatogenesis in mice with busulfan-induced azoospermia.Clinical and experimental reproductive medicine · 2025Article
- The E3 ligase OsHel2 impedes readthrough of stalled mRNAs to regulate male fertility in thermosensitive genic male sterile rice.Plant communications · 2025Article
- Coevolution and Adaptation of Transition Nuclear Proteins and Protamines in Naturally Ascrotal Mammals Support the Black Queen Hypothesis.Genome biology and evolution · 2024Article
- Article
- Caffeine attenuates spermatogenic disorders in mice with induced chronic scrotal hyperthermia.Clinical and experimental reproductive medicine · 2024Article
- Effect of Temperature on the Development of Stages of Spermatogenesis and the Functionality of Sertoli Cells In Vitro.International journal of molecular sciences · 2024Article
- Retinoic acid loaded with chitosan nanoparticles improves spermatogenesis in scrotal hyperthermia in mice.Clinical and experimental reproductive medicine · 2023Article
- Functional histology of human scrotal wall layers and their overlooked relation with infertility: a narrative review.International journal of impotence research · 2023Review
- Article
- An Assessment of Men Semen Alterations in SARS-CoV-2: Is Fever the Principal Concern?Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Chronic scrotal heat stress causes testicular interstitial inflammation and fibrosis: An experimental study in mice.International journal of reproductive biomedicine · 2022Article
- The impact of COVID-19 on human reproduction and directions for fertility treatment during the pandemic.Clinical and experimental reproductive medicine · 2021Article
- Comparative genomics reveals molecular mechanisms underlying health and reproduction in cryptorchid mammals.BMC genomics · 2021Article
- Use of Infrared Thermography during Ejaculation Process and Its Link with Semen Quality and Freezability in Dogs.Animals : an open access journal from MDPI · 2021Article
- The effect of seasonality on reproductive outcome of patients undergoing intracytoplasmic sperm injection: A descriptive cross-sectional study.International journal of reproductive biomedicine · 2020Review
- Reconstruction of the Necrotic Scrotum with Hydrosurgery System and Pedicle DIEP Flap: A Case Report of Fournier Gangrene.Plastic and reconstructive surgery. Global open · 2020Article
- DNA damage in human sperm: The sperm chromosome assay.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA mild increase in testicular and epididymal temperatures in men, bulls and rams (pendulous scrotum) inhibits spermatogenesis and increases the percentage of sperm with an abnormal morphology. However, the stages of spermatogenesis that are most sensitive to a mild increase in testicular temperature in men are unknown. The aim of the present study was to explore the effects of a mild induced increase in testicular and epididymal temperature (i.e., testicular temperature maintained below the core body temperature) on sperm morphology in humans depending on the physiological time of spermatogenesis and epididymal transit.
methodsFive healthy volunteers were enrolled in an experimental study in which testicular and epididymal temperatures were increased by maintaining the testes in a supra-scrotal position with a specially designed underwear worn 15±1 h a day for 120 consecutive days. Semen collection was scheduled on specific days depending on spermatogenic stages and epididymal transit.
resultsSperm morphology and the multiple anomalies index (MAI) were analysed before, during and after heating. This mild induced increase in testicular and epididymal temperatures resulted in a significant rise in the percentage of morphologically abnormal spermatozoa on day 34 of heating, which remained elevated throughout the heating period and persisted until 45 days after cessation of heating. The MAI was significantly increased on day 20 throughout the heating period and persisted 45 days after cessation of heating. An increase in the percentage of anomalies in the sperm head, acrosome or tail occurred on days 34 and/or 45 of heating. Abnormal sperm morphology and MAI reverted to control values 73 days after cessation of heating.
conclusionsA mild sustained increase in testicular and epididymal temperature in man leads morphological abnormalities in spermatozoa mainly due to an impairment of spermiogenesis and meiosis.
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