ArticleFrontiers in genetics2019
m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- The mechanism of m6A methylation analysis of the transcriptome to regulate the diameter of Alpine Merino wool fiber.Animal bioscience · 2026Article
- Transcriptome-wide study of mRNAs modified by mAnimal biotechnology · 2025Article
- NZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Deciphering the molecular drivers for cashmere/pashmina fiber production in goats: a comprehensive review.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Correlation and regression analysis of KRT35 and TCHHL1 functional genes for cashmere fineness in Liaoning cashmere goats.Journal, genetic engineering & biotechnology · 2024Article
- Comprehensive analysis of the expression profiles of mRNA, lncRNA, circRNA, and miRNA in primary hair follicles of coarse sheep fetal skin.BMC genomics · 2024Article
- Multi-omics analysis of functional substances and expression verification in cashmere fineness.BMC genomics · 2023Article
- Article
- Genome-wide DNA methylation and transcriptome analyses reveal the key gene for wool type variation in sheep.Journal of animal science and biotechnology · 2023Article
- Transcriptome-wide analysis of RNA mBMC genomics · 2023Article
- The Characterization and Differential Analysis of mAnimals : an open access journal from MDPI · 2023Article
- Research Progress of mBioMed research international · 2023Review
- Article
- m6A modification of mRNA in skin diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Article
- The m6A methylation regulates gonadal sex differentiation in chicken embryo.Journal of animal science and biotechnology · 2022Article
- Function of m6A and its regulation of domesticated animals' complex traits.Journal of animal science · 2022Review
- Transcriptome-Wide m6A Methylome and m6A-Modified Gene Analysis in Asthma.Frontiers in cell and developmental biology · 2022Article
- The role of RNA m6A methylation in lipid metabolism.Frontiers in endocrinology · 2022Review
- Identification and functional analysis of mFrontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N6-methyladenosine (m6A) is the most common internal modification in mRNAs of all higher eukaryotes. Here we perform two high-throughput sequencing methods, m6A-modified RNA immunoprecipitation sequence (MeRIP-seq) and RNA sequence (RNA-seq) to identify key genes with m6A modification in cashmere fiber growth. A total of 9,085 m6A sites were differentially RNA m6A methylated as reported from by MeRIP-seq, including 7,170 upregulated and 1,915 downregulated. In addition, by comparing m6A-modified genes between the fine-type Liaoning cashmere goat (FT-LCG) and coarse-type Liaoning Cashmere Goat (CT-LCG) skin samples, we obtain 1,170 differentially expressed genes. In order to identify the differently methylated genes related to cashmere fiber growth, 19 genes were selected to validate by performing qRT-PCR in FT-LCG and CT-LCG. In addition, GO enrichment analysis shows that differently methylated genes are mainly involved in keratin filament and intermediate filament. These findings provide a theoretical basis for future research on the function of m6A modification during the growth of cashmere fiber.
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