Evidence map›Paper›PMID 32038647›Full record

ArticleFrontiers in immunology2019

ADAP Promotes Degranulation and Migration of NK Cells Primed During

Martha A L Böning, Stephanie Trittel, Peggy Riese, Marco van Ham, Maxi Heyner, Martin Voss, Gerald P Parzmair, Frank Klawonn, Andreas Jeron, Carlos A Guzman and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Acetylation and Deacetylation of Cytoskeleton-Associated Proteins.Results and problems in cell differentiation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Martha A L BöningInfection Immunology Group, Institute of Medical Microbiology, Infection Control and Prevention, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Stephanie TrittelVaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Peggy RieseVaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Marco van HamCellular Proteome Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Maxi HeynerCellular Proteome Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Martin VossInstitute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Gerald P ParzmairInstitute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Frank KlawonnCellular Proteome Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Andreas JeronInfection Immunology Group, Institute of Medical Microbiology, Infection Control and Prevention, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Carlos A GuzmanVaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Lothar JänschCellular Proteome Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Burkhart SchravenInstitute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Annegret ReinholdInstitute of Molecular and Clinical Immunology, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Dunja BruderInfection Immunology Group, Institute of Medical Microbiology, Infection Control and Prevention, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Helmholtz Centre for Infection Research · DEOtto-von-Guericke University Magdeburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adhesion and degranulation-promoting adaptor protein (ADAP) serves as a multifunctional scaffold and is involved in the formation of immune signaling complexes. To date only limited and moreover conflicting data exist regarding the role of ADAP in NK cells. To extend existing knowledge we investigated ADAP-dependency of NK cells in the context of

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBiomarkersCell DegranulationCell MovementCytokinesDisease Models, AnimalImmunophenotypingKiller Cells, NaturalListeria monocytogenesListeriosisMiceMice, KnockoutProteomeProteomicsAdaptor Proteins, Signal TransducingBiomarkersCytokinesFyb protein, mouseProteomeADAPCD11acytotoxicityIL-10in vivo infectionListeria monocytogenesmigrationnatural killer cells

Identifiers

PMID32038647
PMCPMC6987423
OpenAlexW3001634530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.