Evidence map›Paper›PMID 32038644›Full record

ReviewFrontiers in immunology2019

Extracellular Vesicles in Glioblastoma Tumor Microenvironment.

Anuroop Yekula, Anudeep Yekula, Koushik Muralidharan, Keiko Kang, Bob S Carter, Leonora Balaj

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anuroop YekulaGovernment General Hospital, Guntur Medical College, Guntur, India.
Anudeep YekulaDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Koushik MuralidharanDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Keiko KangDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Bob S CarterDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Leonora BalajDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9M
Liquid Biopsy for treatment stratification of IDH1.R132H and EGFRvIII mutant gliomasU01CA230697 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, SKOG, JOHAN · 2018 to 2022
$4.0M
exRNA Biomarkers for Human GliomaUH3TR000931 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARTER, BOB S, HOCHBERG, FRED H · 2015 to 2017
$3.0M
NCATS NIH HHS UH3 TR000931NCI NIH HHS P01 CA069246NCI NIH HHS U01 CA230697
6 · The paper itself

Abstract

Glioblastomas (GBM) are highly aggressive primary brain tumors. Complex and dynamic tumor microenvironment (TME) plays a crucial role in the sustained growth, proliferation, and invasion of GBM. Several means of intercellular communication have been documented between glioma cells and the TME, including growth factors, cytokines, chemokines as well as extracellular vesicles (EVs). EVs carry functional genomic and proteomic cargo from their parental cells and deliver that information to surrounding and distant recipient cells to modulate their behavior. EVs are emerging as crucial mediators of establishment and maintenance of the tumor by modulating the TME into a tumor promoting system. Herein we review recent literature in the context of GBM TME and the means by which EVs modulate tumor proliferation, reprogram metabolic activity, induce angiogenesis, escape immune surveillance, acquire drug resistance and undergo invasion. Understanding the multifaceted roles of EVs in the niche of GBM TME will provide invaluable insights into understanding the biology of GBM and provide functional insights into the dynamic EV-mediated intercellular communication during gliomagenesis, creating new opportunities for GBM diagnostics and therapeutics.

Indexed as

AnimalsBrain NeoplasmsCytokinesExtracellular VesiclesGlioblastomaHumansIntercellular Signaling Peptides and ProteinsTumor MicroenvironmentCytokinesIntercellular Signaling Peptides and Proteinsangiogenesisextracellular vesiclesglioblastomaimmunomodulationtumor microenvironment

Identifiers

PMID32038644
PMCPMC6990128

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.