ReviewFrontiers in neurology2019
The Association of Autonomic Nervous System Function With Ischemic Stroke, and Treatment Strategies.
Review in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Thermography in Stroke-A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia.Cell discovery · 2026Article
- Prognostic value of heart rate variability for neurological outcomes in cardiac arrest patients: machine learning-based analysis of the International Cardiac Arrest Research (I-CARE) database.Resuscitation plus · 2026Article
- Albumin levels and risk of early cardiovascular complications after endovascular thrombectomy for acute ischaemic stroke.Scientific reports · 2026Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Autonomic dysfunction after stroke: an overview of recent clinical evidence and perspectives on therapeutic management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Heart Rate Variability and Autonomic Dysfunction After Stroke: Prognostic Markers for Recovery.Biomedicines · 2025Review
- Article
- Early heart rate predicts 3-month outcomes in acute ischemic stroke patients receiving intravenous thrombolysis: a machine learning approach.Frontiers in neurology · 2025Article
- Impact of diabetes mellitus on 30-day mortality among acute stroke patients in northern Tanzania.PloS one · 2025Article
- When the Heart and Brain Collide: A Case of Malignant Middle Coronary Artery Infarction and Cardiac Arrhythmias Linked to Right Insular Cortex Dysfunction.European journal of case reports in internal medicine · 2025Article
- Impact of heart rate on eGFR decline in ischemic stroke patients.Clinical kidney journal · 2025Article
- Heart rate variability in chronic ischemic stroke: analysis during the sleep-wake cycle.Arquivos de neuro-psiquiatria · 2024Article
- Assessing Children's Autonomic Nervous System Activity During Structured Tasks: A Feasibility and Reliability Study in Ghana.Developmental psychobiology · 2024Article
- Heart Rate Variability and Functional Outcomes of Patients with Spontaneous Intracerebral Hemorrhage.Biomedicines · 2024Article
- Effect of heart rate on poor outcome in stroke patients treated with intra-arterial thrombectomy.BMC neurology · 2024Article
- Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies.GeroScience · 2024Review
- Cardiovascular Reflexes - Vagus as the Key Player.Current cardiology reviews · 2024Review
- Changes in beat-to-beat blood pressure and pulse rate variability following stroke.Scientific reports · 2023Article
- Serum NT-proBNP level for predicting functional outcomes after acute ischemic stroke.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute ischemic stroke, especially minor stroke, and transient ischemic attack have high risks of recurrence and exacerbation into severe ischemic strokes. It remains challenging to perform risk stratification and screen high-risk groups for initiation of early treatment in these patients. Moreover, with the growing population of patients with chronic small vessel disease, the mechanisms and clinical implications require further investigation. Traditional tools such as the ABCD2 score (age, blood pressure, clinical features, duration of symptoms, diabetes) have only moderate predictive value in patients with transient ischemic attack or minor stroke. By contrast, measurement of changes in heart rate variability (HRV) is an important and novel tool for risk stratification and outcome prediction in patients with cardiovascular diseases, as it reflects the overall level of autonomic nervous system dysfunction. Thus, abnormal HRV may be useful for prognosis and improve stratification of stroke patients with diverse risks. HRV may also partially explain autonomic nervous dysfunction and other manifestations during the process of chronic cerebral small vessel disease. In summary, measurement of HRV may contribute to early initiation of interventions in acute or chronic stroke patients using novel treatments involving rebalancing of autonomic nervous system function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.