Evidence map›Paper›PMID 32038456›Full record

ArticleFrontiers in neurology2019

High Levels of Epstein-Barr Virus Nuclear Antigen-1-Specific Antibodies and Infectious Mononucleosis Act Both Independently and Synergistically to Increase Multiple Sclerosis Risk.

Anna Karin Hedström, Jesse Huang, Angelica Michel, Julia Butt, Nicole Brenner, Jan Hillert, Tim Waterboer, Ingrid Kockum, Tomas Olsson, Lars Alfredsson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. EBV Genome Variations and Association With Diseases.Journal of medical virology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anna Karin HedströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Jesse HuangDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Angelica MichelInfections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Julia ButtInfections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Nicole BrennerInfections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Jan HillertDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Tim WaterboerInfections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Ingrid KockumDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Tomas OlssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEHeidelberg University · DEGerman Cancer Research Center · DEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anti-EBNA-1 antibodiesEpstein–Barr virus infectionhuman leukocyte antigeninfectious mononucleosismultiple sclerosis

Identifiers

PMID32038456
PMCPMC6992610
OpenAlexW3002196184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.