ArticleFrontiers in psychiatry2019
Decreased Task-Related HRV Is Associated With Inhibitory Dysfunction Through Functional Inter-Region Connectivity of PFC in Major Depressive Disorder.
Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Is cardiac autonomic control affected in major depressive disorder? A systematic review of heart rate variability studies.Translational psychiatry · 2025Pooled it
- Brain-heart interactions in late-onset major depressive disorder revealed by multimodal HRV-driven fMRI.Communications biology · 2026Article
- Artificial intelligence in neurocardiology: decoding brain-heart network interactions for clinical and translational insights.Frontiers in neuroscience · 2026Review
- M-ECG: extracting heart signals with a novel computational analysis of magnetoencephalography data.Frontiers in neuroimaging · 2025Article
- Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder.Molecular psychiatry · 2024Review
- Screening for Major Depressive Disorder Using a Wearable Ultra-Short-Term HRV Monitor and Signal Quality Indices.Sensors (Basel, Switzerland) · 2023Article
- Insular dysfunction of interoception in major depressive disorder: from the perspective of neuroimaging.Frontiers in psychiatry · 2023Review
- Heart rate variability in late pregnancy: exploration of distinctive patterns in relation to maternal mental health.Translational psychiatry · 2021Article
- Prescription opioid misusers exhibit blunted parasympathetic regulation during inhibitory control challenge.Psychopharmacology · 2021Article
- Two-Hour Tobacco Abstinence Has No Effect on Cognitive Control in Male Patients With Nicotine Dependence: An ERP Study.Frontiers in psychiatry · 2020Article
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10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation of the autonomic nervous system (ANS) can improve cognitive function in major depressive disorders (MDD). Heart rate variability (HRV) derives from the dynamic control of the ANS and reflects the balance between the activities of the sympathetic and parasympathetic nervous systems by measuring tiny changes in adjacent heart beats. Task-related HRV may reflect the association between the flexibility of cognition and ANS function. The study was to investigate the neural mechanism of interactions between ANS and cognitive function in MDD with Magnetoencephalography (MEG) measurements. Participants included 20 MDD patients and 18 healthy controls (HCs). All participants were measured with a go/no-go task MEG. HRV indices, the standard deviation of the average normal-to-normal (NN) interval calculated over short periods (SDANN) and the square root of the mean squared differences of successive NN intervals (RMSSD), were derived from the raw MEG data. Results showed that MDD patients showed decreased SDANN and RMSSD. In MDD patients, both resting-state and task-related RMSSD were related to inhibitory and control dysfunction. In the go/no-go task, many areas in the prefrontal cortex (PFC) are responsible for an individual's inhibitory function. A brain MEG functional connectivity analysis revealed that there were significant differences in four brain regions within the prefrontal cortex (PFC) between MDD patients and HCs. Task-related RMSSD in HCs were related to the functional connectivity between the left middle frontal gyrus and the anterior cingulate cortex (ACC), while in MDD patients, these values were not related to the above functional connectivity but were related to the functional connectivity between the left middle frontal gyrus and insula. However, the resting-state RMSSD value was not related to these significant difference functional connectivity networks in all participants. It concludes that the decreased task-related HRV is associated with inhibitory dysfunction through functional inter-region connectivity in the PFC in MDD, and the task-related HRV can be used as an index of the association between MDD and autonomic dysregulation.
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