ArticleFrontiers in psychiatry2019
Cognitive Distortions in Relation to Plasma Cortisol and Oxytocin Levels in Major Depressive Disorder.
Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Olympic combat sports and mental health in children and adolescents with disability: a systematic review of controlled trials.Frontiers in psychology · 2025Pooled it
- Cortisol, cardiovascular risk, and anxiety in full-time workers in Cartagena, Colombia, 2023.Frontiers in psychiatry · 2025Article
- Plasma neuropeptide levels in patients with schizophrenia, bipolar disorder, or major depressive disorder and healthy controls: A multiplex immunoassay study.Neuropsychopharmacology reports · 2023Article
- Promising applications of human-derived saliva biomarker testing in clinical diagnostics.International journal of oral science · 2023Review
- High Plasma Oxytocin Levels in Men With Hypersexual Disorder.The Journal of clinical endocrinology and metabolism · 2022Article
- Effects of intranasal oxytocin on the self-perception and anxiety of singers during a simulated public singing performance: A randomized, placebo-controlled trial.Frontiers in neuroscience · 2022Article
- Discussions and perspectives regarding oxytocin as a biomarker in human investigations.Heliyon · 2021Review
- The Interplay between Housing Environmental Attributes and Design Exposures and Psychoneuroimmunology Profile-An Exploratory Review and Analysis Paper in the Cancer Survivors' Mental Health Morbidity Context.International journal of environmental research and public health · 2021Review
- Cortisol in relation to problematic eating behaviours, adiposity and symptom profiles in Major Depressive Disorder.Comprehensive psychoneuroendocrinology · 2021Article
- Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies.Molecular neurobiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Negative thinking is prominent in major depressive disorder (MDD). Cognitive models propose that negative thinking influences the hypothalamus-pituitary-adrenal axis and cortisol release. Oxytocin is also linked to MDD, social and affective processing, and stress buffering. Little research has examined direct relationships between negative cognitions, cortisol, and oxytocin.
methodsSixty-one unmedicated participants meeting DSM-5 criteria for MDD and 60 healthy controls completed measures of psychopathology, stress, and cognitions. Plasma samples were analyzed for cortisol and oxytocin. Between-group analyses of variance were conducted along with correlational, regression and mediation analyses.
resultsDepressed participants reported greater frequency and believability of negative thoughts than controls. Cortisol levels were positively, and oxytocin inversely, correlated with negative thinking. Cortisol and negative thinking accounted for unique variance in depression, and the relationship between stress and cortisol depended on the extent of negative cognitions.
conclusionsThe results support long-standing cognitive models which propose that negative thoughts are important in the relationship between stress and cortisol levels.
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