Evidence map›Paper›PMID 32038254›Full record

ArticleFrontiers in pharmacology2019

Identification of a Selective PDE4B Inhibitor From

Estela M G Lourenço, Júlia M Fernandes, Vinícius de F Carvalho, Raphael Grougnet, Marco A Martins, Alessandro K Jordão, Silvana M Zucolotto, Euzébio G Barbosa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Frontiers in pharmacology · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Bioactive Compounds fromLife (Basel, Switzerland) · 2023
    Review
  7. Repurposing ofFrontiers in pharmacology · 2023
    Article
  8. Gel formulated withFrontiers in pharmacology · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Estela M G LourençoLaboratório de Química Farmacêutica Computacional, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Júlia M FernandesLaboratório de Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Vinícius de F CarvalhoLaboratório de Inflamação, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Raphael GrougnetLaboratoire de Pharmacognosie, Faculté de Pharmacie, Université Paris Descartes, Paris, France.
Marco A MartinsLaboratório de Inflamação, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Alessandro K JordãoLaboratório de Química Farmacêutica Computacional, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Silvana M ZucolottoLaboratório de Produtos Naturais Bioativos, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Euzébio G BarbosaLaboratório de Química Farmacêutica Computacional, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Universidade Federal do Rio Grande do Norte · BRFundação Oswaldo Cruz · BRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products are considered an important source of bioactive compounds especially in biodiversity-rich countries like Brazil. The identification of potential targets is crucial to the development of drugs from natural sources. In this context,

Indexed as

Bryophyllum pinnatumFlavonoidinverse virtual screeningmolecular dynamicsnatural productsPDE4

Identifiers

PMID32038254
PMCPMC6987432
OpenAlexW3001697848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.