Evidence map›Paper›PMID 32038165›Full record

ArticleFrontiers in molecular neuroscience2019

Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington's Disease Patients.

Ashley Gutierrez, Jody Corey-Bloom, Elizabeth A Thomas, Paula Desplats

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  4. Disruption of BDNF signalling in neuropathologies.Biochemical Society transactions · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ashley GutierrezDepartment of Neuroscience, School of Medicine, University of California, San Diego, San Diego, CA, United States.
Jody Corey-BloomDepartment of Neuroscience, School of Medicine, University of California, San Diego, San Diego, CA, United States.
Elizabeth A ThomasDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, United States.
Paula DesplatsDepartment of Neuroscience, School of Medicine, University of California, San Diego, San Diego, CA, United States.
University of California, San Diego · USScripps Research Institute · US

Funding

Exploration of salivary huntingtin for biomarker discoveryR21NS111655 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMAS, ELIZABETH A · 2019 to 2020
$425k
Applying DNA methylation for differential diagnosis in Lewy Body DementiaR03NS104013 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DESPLATS, PAULA ALEJANDRA · 2017 to 2018
$155k
NINDS NIH HHS R03 NS104013NINDS NIH HHS R21 NS111655
6 · The paper itself

Abstract

Huntington's disease (HD) is an autosomal-dominant neurodegenerative movement disorder that presents with prominent cognitive and psychiatric dysfunction. Brain-derived neurotrophic factor (BDNF) plays an important role in the pathophysiology of HD, as well as other neurodegenerative and psychiatric disorders, and epigenetic alterations in the complex BDNF promoter have been associated with its deregulation in pathological conditions. BDNF has gained increased attention as a potential biomarker of disease; but currently, the conflicting results from measurements of BDNF in different biofluids difficult the assessment of its utility as a biomarker for HD. Here, we measured BDNF protein levels in plasma (

Indexed as

biomarkerbloodbrain-derived neurotrophic factorclinical symptomsDNA methylationepigeneticsHuntington’s diseasesaliva

Identifiers

PMID32038165
PMCPMC6989488
OpenAlexW3001101218

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.