ArticleIranian journal of medical sciences2020
The Effect of Voluntary Exercise and Prenatal Exposure to Sodium Valproate on Learning, Memory, and Anxiety of Rats' Offspring.
Article in Iranian journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- The Effect of Valproic Acid Administration on Learning, Social Interaction, and Depression Induced by Withdrawal Syndrome in Morphine-dependent Mice.Addiction & health · 2024Article
- Exercise before pregnancy exerts protective effect on prenatal stress-induced impairment of memory, neurogenesis, and mitochondrial function in offspring.Journal of exercise rehabilitation · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntiepileptic drugs, such as sodium valproate (SV), are teratogenic as their usage by the pregnant mother has been associated with an increased risk of major congenital abnormalities in the fetus. In this study, the effects of voluntary exercise and prenatal exposure to SV on learning, memory, and anxiety in rats' offspring are investigated.
methodsIn the present study, 70 female albino Wistar rats (200-240g) were used. The rats were categorized in seven groups: 1 and 2, pregnant rats with exposure to SV (10 mg/kg/day i.p) 3 and 4, pregnant rats with exposure to SV (20 mg/kg/day i.p) 5 and 6, pregnant rats with exposure to normal saline (0.4 ml/day i.p) and 7, pregnant rats with exposure to lamotrigine (20 mg/kg/day i.p). The even and odd groups were sedentary and voluntary exercise groups, respectively. Learning and memory were tested in male offspring using shuttle-box; anxiety was tested by elevated plus-maze (each group n=12). Statistical analyses were performed using the one-way ANOVA (the Tukey test) and/or two-way ANOVA on rank.
resultsThe results showed that voluntary exercise in male rats caused improvement of latency and duration time in the dark box compared to sedentary groups (P=0.004). Moreover, the group administrated with 10 mg/kg SV showed better learning capability than the group administrated with 20 mg/kg SV. Voluntary exercise could also improve anxiety (P=0.001).
conclusionThis study indicated that exercise could increase learning capacity and improve memories in rats' offspring whose mothers were exposed to SV. Voluntary exercise could improve anxiety too, and the effect was dose-dependent.
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