ArticleClinical and translational medicine2020
Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer.
Article in Clinical and translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Trans-ancestry analysis in over 799,000 individuals yields new insights into the genetic etiology of colorectal cancer.PloS one · 2024Pooled it
- AllergoOncology: Emerging Translational and Clinical Significance of Basophils and Mast Cells in Cancer.Clinical and translational allergy · 2026Review
- Causal roles of immune cells and plasma metabolites in esophageal cancer: A Mendelian randomization study with nutritional insights.Asia Pacific journal of clinical nutrition · 2026Article
- Human blood cell traits and sporadic lymphangioleiomyomatosis: results from mediation joint multi-omics and eQTL Mendelian randomization analysis.Orphanet journal of rare diseases · 2026Article
- Influencing factors of prognosis in HIV infected individuals undergoing surgical treatment for colorectal cancer.Frontiers in oncology · 2026Article
- The value of complete blood count parameters in the preoperative diagnosis of parathyroid tumor.Gland surgery · 2025Article
- Review
- Transcriptome-wide Mendelian randomisation exploring dynamic CD4+ T cell gene expression in colorectal cancer development.medRxiv : the preprint server for health sciences · 2025Article
- Decision tree model for predicting ovarian tumor malignancy based on clinical markers and preoperative circulating blood cells.BMC medical informatics and decision making · 2025Article
- Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment.Journal of immunology research · 2025Review
- The Predictive Value of the Cholesterol-to-Natural Killer Cell Ratio in Colorectal Cancer.Journal of Cancer · 2025Article
- Machine Learning-based Prognostic Model for Brain Metastasis Patients: Insights from Blood Test Analysis.Journal of Cancer · 2025Article
- Immune mediated support of metastasis: Implication for bone invasion.Cancer communications (London, England) · 2024Review
- IL3-Driven T Cell-Basophil Crosstalk Enhances Antitumor Immunity.Cancer immunology research · 2024Article
- Genetic Evidence for a Causal Relationship Between Innate Leukocytes and the Risk of Digestive System Cancers in East Asians and Europeans.World journal of oncology · 2024Article
- Eosinophils in Colorectal Cancer: Emerging Insights into Anti-Tumoral Mechanisms and Clinical Implications.International journal of molecular sciences · 2024Review
- Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomisation study.International journal of cancer · 2024Article
- Basophils may as a risk factor for upper gastrointestinal cancer: a Mendelian randomization (MR) study.Ecancermedicalscience · 2024Article
- Exploiting innate immunity for cancer immunotherapy.Molecular cancer · 2023Review
- Inflammation in Prostate Cancer: Exploring the Promising Role of Phenolic Compounds as an Innovative Therapeutic Approach.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAccumulating evidence demonstrated immune/inflammation-related implications of basophils in affecting tissue microenvironment that surrounded a tumor, and this study aimed to elucidate the clinical value of serum basophil count level.
methodsBetween December 2007 and September 2013, 1029 patients diagnosed with stage I-III CRC in Fudan University Shanghai Cancer Center meeting the essential criteria were identified. The Kaplan-Meier method was used to construct the survival curves. Several Cox proportional hazard models were constructed to assess the prognostic factors. A simple predictor (CB classifier) was generated by combining serum basophil count and serum carcinoembryonic antigen (CEA) level which had long been accepted as the most important and reliable prognostic factor in CRC.
resultsThe preoperative basophils count < 0.025*10
conclusionsAs a common immune/inflammation-related biomarker available from the blood routine examination, low level of preoperative serum basophil count was associated with aggressive biology and indicated evidently poor survival. Preoperative serum basophil count would be a useful and simple marker for the management of CRC patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.