Evidence map›Paper›PMID 32037478›Full record

ReviewCurrent environmental health reports2020

Synthetic Chemicals and Cardiometabolic Health Across the Life Course Among Vulnerable Populations: a Review of the Literature from 2018 to 2019.

Symielle A Gaston, Linda S Birnbaum, Chandra L Jackson

Abstract readReview
In one paragraph

Review in Current environmental health reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Comprehensive Analysis of Mango (Food science & nutrition · 2025
    Article
  6. The role of per- and polyfluoroalkyl substances in cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
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  13. Article
  14. Article
  15. Acetochlor Affects Bighead Carp (BioMed research international · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Symielle A GastonEpidemiology Branch, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, 111 TW Alexander Drive, MD A3-05, Research Triangle Park, NC, 27709, USA.ORCID 0000-0001-9495-1592
Linda S BirnbaumOffice of the Director, National Institute of Environmental Health Sciences and the National Toxicology Program, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC, USA.ORCID 0000-0001-5429-5658
Chandra L JacksonEpidemiology Branch, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, 111 TW Alexander Drive, MD A3-05, Research Triangle Park, NC, 27709, USA. Chandra.Jackson@nih.gov.ORCID 0000-0002-0915-8272

Funding

Social and Environmental Determinants of Health EquityZIAES103325 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JACKSON, CHANDRA · 2017 to 2025
$12.7M
Environmental Toxicokinetics and ToxicologyZIAES103348 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CANNON, RONALD E. · 2020 to 2021
$4.3M
Intramural NIH HHS ZIA ES103325
6 · The paper itself

Abstract

purpose of reviewAlthough vulnerable populations are disproportionately exposed to synthetic chemicals with endocrine disrupting properties, few recent reviews have summarized the impact of synthetic chemicals on cardiometabolic health among these groups. RECENT

findingsOf 37 eligible epidemiological studies among vulnerable populations published between January 2018 and April 2019 in which over half were prospective, the most investigated populations were pregnant women and children. Racial/ethnic minorities, individuals of low socioeconomic status (SES), and those occupationally exposed were studied the least. The most studied persistent organic pollutants (POPs) were per-/poly-fluoroalkyl substances (PFAS), and the most studied non-POPs were phenols. Across chemical classes, studies found certain POPs (e.g., PFAS) and non-POPs (i.e., phenols, phthalates, and parabens) to be associated with gestational diabetes and dysregulated glucose metabolism. Results for other cardiometabolic health outcomes were inconsistent but suggested certain chemicals may negatively affect cardiometabolic health. Synthetic chemicals likely adversely affect cardiometabolic health, but current findings were inconclusive. Few recent studies focused on racial/ethnic minorities, low SES, and occupationally exposed populations. To address poor cardiometabolic health and related disparities, more studies across vulnerable populations are warranted.

Indexed as

Cardiovascular DiseasesEndocrine DisruptorsEnvironmental PollutantsFemaleHealthHumansParabensPhenolsPhthalic AcidsPregnancyProspective StudiesVulnerable PopulationsEndocrine DisruptorsEnvironmental PollutantsParabensPhenolsphthalic acidPhthalic AcidsCardiovascular diseasesEndocrine disruptorsMetabolic diseasesMinority healthPregnancy complicationsVulnerable populations

Identifiers

PMID32037478
PMCPMC7187897

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.