Evidence map›Paper›PMID 32037400›Full record

ArticleBritish journal of cancer2020

Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells.

Carlos Alberto Aya-Bonilla, Michael Morici, Xin Hong, Ashleigh Cavell McEvoy, Ryan Joseph Sullivan, James Freeman, Leslie Calapre, Muhammad Adnan Khattak, Tarek Meniawy, Michael Millward and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 59 citations in OpenAlex.

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  15. The journey from melanocytes to melanoma.Nature reviews. Cancer · 2023
    Review
  16. Circulating tumour cell isolation, analysis and clinical application.Cellular oncology (Dordrecht, Netherlands) · 2023
    Review
  17. Recent Advances in Methods for Circulating Tumor Cell Detection.International journal of molecular sciences · 2023
    Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Carlos Alberto Aya-BonillaSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Michael MoriciSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Xin HongMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Ashleigh Cavell McEvoySchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Ryan Joseph SullivanMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
James FreemanSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Leslie CalapreSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Muhammad Adnan KhattakSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Tarek MeniawySchool of Medicine, University of Western Australia, Crawley, WA, Australia.
Michael MillwardSchool of Medicine, University of Western Australia, Crawley, WA, Australia.
Mel ZimanSchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Elin Solomonovna GraySchool of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia. e.gray@ecu.edu.au.ORCID http://orcid.org/0000-0002-8613-3570
Edith Cowan University · AUHarvard University · USThe University of Western Australia · AU

Funding

Cancer Council Western Australia NA
6 · The paper itself

Abstract

backgroundCirculating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application.

methodsHere we compared two microfluidic devices for the recovery of circulating melanoma cells. The presence of CTCs in 43 blood samples from patients with metastatic melanoma was evaluated using a combination of immunocytochemistry and transcript analyses of five genes by RT-PCR and 19 genes by droplet digital PCR (ddPCR), whereby a CTC score was calculated. Circulating tumour DNA (ctDNA) from the same patient blood sample, was assessed by ddPCR targeting tumour-specific mutations.

resultsOur analysis revealed an extraordinary heterogeneity amongst melanoma CTCs, with multiple non-overlapping subpopulations. CTC detection using our multimarker approach was associated with shorter overall and progression-free survival. Finally, we found that CTC scores correlated with plasma ctDNA concentrations and had similar pharmacodynamic changes upon treatment initiation.

conclusionsDespite the high phenotypic and molecular heterogeneity of melanoma CTCs, multimarker derived CTC scores could serve as viable tools for prognostication and treatment response monitoring in patients with metastatic melanoma.

Indexed as

Case-Control StudiesCell Line, TumorFemaleHumansMaleMelanomaNeoplastic Cells, CirculatingPrognosis

Identifiers

PMID32037400
PMCPMC7109152
OpenAlexW3005106264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.