Evidence map›Paper›PMID 32036697›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Urethral dysfunction in a rat model of chemically induced prostatic inflammation: potential involvement of the MRP5 pump.

Eduardo C Alexandre, Nailong Cao, Shinsuke Mizoguchi, Tetsuichi Saito, Masahiro Kurobe, Daisuke Gotoh, Meri Okorie, Taro Igarashi, Edson Antunes, Naoki Yoshimura

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Eduardo C AlexandreDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-9482-6799
Nailong CaoDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Shinsuke MizoguchiDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Tetsuichi SaitoDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Masahiro KurobeDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Daisuke GotohDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Meri OkorieDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Taro IgarashiDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Edson AntunesDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.ORCID 0000-0003-2201-8247
Naoki YoshimuraDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0001-8070-1664
University of Pittsburgh · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

University of Pittsburgh O'Brien Cooperative Research Center ProgramU54DK112079 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEFRANCO, DONALD B · 2016 to 2020
$6.5M
NIDDK NIH HHS U54 DK112079
6 · The paper itself

Abstract

Prostate inflammation (PI) is a clinical condition associated with infection and/or inflammation of the prostate. It is a common disease frequently associated to lower urinary tract (LUT) symptoms. The urethra is an understudied structure in the LUT and plays a fundamental role in the urinary cycle. Here, we proposed to evaluate the effect of PI on the urethra tissue. Male Sprague-Dawley rats were used, and PI was induced by formalin injection into the ventral lobes of the prostate. The pelvic urethra at the prostatic level was harvested for histological analysis, contraction (electrical field stimulation and phenylephrine), and relaxation (sodium nitroprusside/MK-571) experiments. Various gene targets [cytochrome

Indexed as

AnimalsATP-Binding Cassette, Sub-Family C ProteinsCytokinesFormaldehydeGene Expression RegulationInflammationMaleProstateProstatitisRatsRats, Sprague-DawleyRNA, MessengerUrethral DiseasesAbcc5 protein, ratATP-Binding Cassette, Sub-Family C ProteinsCytokinesFormaldehydeRNA, MessengercGMPelectrical field stimulationmultidrug resistance-associated protein 5phenylephrineprostatitis

Identifiers

PMID32036697
PMCPMC7099503
OpenAlexW3006329943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.