Evidence map›Paper›PMID 32036611›Full record

ArticleJournal of nephrology2020

Anaphylatoxins enhance Th9 cell recruitment via the CCL20-CCR6 axis in IgA nephropathy.

Xinyue Hu, Juntao Feng, Shuanglinzi Deng, Jiale Tang, Zhonghua Liao, Lisha Luo, Liying Luo, Ting Meng, Guanghui Gong, Xiaozhao Li

Abstract read
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In one paragraph

Article in Journal of nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Circulating and Urinary CCL20 in Human Kidney Disease.International journal of molecular sciences · 2025
    Article
  3. Inflammation in glomerular diseases.Frontiers in immunology · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xinyue HuDepartment of Respiratory and Critical Care Medicine, Key Cite of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Juntao FengDepartment of Respiratory and Critical Care Medicine, Key Cite of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Shuanglinzi DengDepartment of Respiratory and Critical Care Medicine, Key Cite of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Jiale TangDepartment of Nephrology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Zhonghua LiaoDepartment of Nephrology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Lisha LuoDepartment of Respiratory and Critical Care Medicine, Key Cite of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Liying LuoDepartment of Nephrology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Ting MengDepartment of Nephrology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Guanghui GongDepartment of Pathology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China.
Xiaozhao LiDepartment of Nephrology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China. lixiaozhao@csu.edu.cn.ORCID http://orcid.org/0000-0003-2222-9095
Central South University · CN

Funding

National Natural Science Foundation of China 81270786National Natural Science Foundation of China 81670027National Natural Science Foundation of China 81800641Natural Science Foundation of Hunan Province 2017JJ3495
6 · The paper itself

Abstract

backgroundCD4

methodsHuman peripheral blood mononuclear cells (PBMCs) were isolated from IgAN patients for Th9 cells detection by flow cytometry. Wild-type (WT) mouse was used to establish an IgAN mouse model while C3aR and C5aR inhibitor treated IgAN mouse. Kidney disease and function was assessed by histology and albumin-to-creatinine ratio. C3aR and C5aR expression was examined by immunohistochemical (IHC) assay. Th9 cell proportions in the blood of IgAN mouse was detected. C3a, C5a and interleukin (IL)-9 levels were tested by ELISA. Moreover, co-culture system between human mesangial cells (HMCs) and CD4

resultsWe observed the numbers of Th9 cell and the levels of IL-9 were increased in IgAN patients and IgAN mice. Furthermore, C3a and C5a level in serum and kidney, C3aR and C5aR expression was increased in IgAN mice compared to WT mice. Most interestingly, C3aR and C5aR inhibitor could reduce kidney damage, Th9 cell numbers and IL-9 levels. We also observed that C3a and C5a enhanced CCL20 production in HMCs. Notably, C3a and C5a also increased the recruitment of Th9 cells and IL-9 levels by HMCs through enhancing the CCL20-CCR6 pathway.

conclusionsOur results support that C3a and C5a increase the production of CCL20 by HMCs and consequently augment Th9 cell recruitment and IL-9 levels, resulting in IgAN exacerbation.

Indexed as

Glomerulonephritis, IGAAnaphylatoxinsAnimalsChemokine CCL20HumansKidneyLeukocytes, MononuclearMiceReceptors, CCR6T-LymphocytesAnaphylatoxinsCCL20 protein, humanCCL20 protein, mouseCCR6 protein, humanCCR6 protein, mouseChemokine CCL20Receptors, CCR6AnaphylatoxinsCCL20-CCR6Human mesangial cellsIgA nephropathyTh9 cells

Identifiers

PMID32036611
OpenAlexW3005287493

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.