ArticleNeurosurgical review2021
Skull base osteomyelitis: clinical and radiologic analysis of a rare and multifaceted pathological entity.
Article in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Test Accuracy and Semi-Quantitative Metrics ofTomography (Ann Arbor, Mich.) · 2026Pooled it
- Necrotic Features in Post-Radiation Nasopharyngeal Biopsies Associated With Carotid Blowout.Laryngoscope investigative otolaryngology · 2026Article
- Personal history of irradiation and risk of osteomyelitis: A Mendelian randomization study.Medicine · 2025Article
- CT-negative central skull base osteomyelitis diagnosed on MRI in the emergency department.BMJ case reports · 2025Article
- Temporoparietal Fascia Flap (TPFF) in Extended Endoscopic Transnasal Skull Base Surgery: Clinical Experience and Systematic Literature Review.Journal of clinical medicine · 2024Review
- Skull base osteomyelitis due to bilateral acute otitis media: Case report and literature review.Radiology case reports · 2024Article
- Skull base infections, their complications, and management.The neuroradiology journal · 2024Review
- Microbial spectrum, management challenges, and outcome in patients with otogenic skull base osteomyelitis.Le infezioni in medicina · 2024Article
- Clinico-Radiological Evaluation for Longitudinal Assessment in Central Skull Base Osteomyelitis: Proposal of Novel Scoring System.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- CT findings in temporal bone sites in skull base osteomyelitis from malignant otitis externa.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Atypical Skull-Base Osteomyelitis: Comprehensive Review and Multidisciplinary Management Viewpoints.Tropical medicine and infectious disease · 2023Review
- Treatment of Skull Base Diseases: A Multidisciplinary Challenge.Journal of clinical medicine · 2023Article
- Endoscopic endonasal resection of craniovertebral junction osteomyelitis: illustrative cases.Journal of neurosurgery. Case lessons · 2023Article
- Treatment of loco-regional recurrence of nasopharyngeal carcinoma in a non-endemic area: oncologic outcomes, morbidity, and proposal of a prognostic nomogram.Frontiers in oncology · 2023Article
- Post-radiotherapy osteomyelitis of the cervical spine in head and neck cancer patients.BJR open · 2023Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skull base osteomyelitis (SBO) is a potentially life-threatening inflammation of cranial base bony structures of variable origin. Criteria for diagnosis and treatment are still controversial. Demographics, predisposing factors, symptoms, imaging, and clinical, laboratory, histological, and microbiological data of patients managed for SBO at the University Hospital of Brescia (ASST Spedali Civili) between 2002 and 2017 were retrospectively reviewed. Patients were included in different etiological groups. The topographic distribution of magnetic resonance (MR) abnormalities was recorded on a bi-dimensional model of skull base, on which three different patterns of inflammatory changes (edematous, solid, or necrotic) were reported. In patients with a history of radiotherapy, the spatial distribution of SBO was compared with irradiation fields. The association between variables and etiological groups was verified with appropriate statistical tests. A classification tree analysis was performed with the aim of inferring a clinical-radiological diagnostic algorithm for SBO. The study included 47 patients, divided into 5 etiological groups: otogenic (n = 5), radio-induced (n = 16), fungal (n = 14), immune-mediated (n = 6), and idiopathic (n = 6). At MR, five types of topographical distribution were identified (central symmetric, central asymmetric, orbital apex, sinonasal, maxillary). In patients with a history of radiotherapy, the probability to develop SBO was significantly increased in areas receiving the highest radiation dosage. The analysis of patients allowed for design of a classification tree for the diagnosis of SBO. The integration of clinical and radiologic information is an efficient strategy to categorize SBO and potentially guide its complex management.
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