Observational studyClinical research in cardiology : official journal of the German Cardiac Society2020
Compared with matched controls, patients with postoperative atrial fibrillation (POAF) have increased long-term AF after CABG, and POAF is further associated with increased ischemic stroke, heart failure and mortality even after adjustment for AF.
Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 6 of them syntheses that pooled it.
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The trial behind it
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Who cites it
40 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Role of vitamin D supplementation in prevention of new onset atrial fibrillation in post-coronary artery bypass graft patients in vitamin D deficient and insufficient populations: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Early postoperative atrial fibrillation is associated with late mortality after cardiac surgery: a systematic review and reconstructed individual patient data meta-analysis.Journal of cardiothoracic surgery · 2025Pooled it
- Incidence of stroke in patients with atrial fibrillation undergoing surgical treatment: a meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Effect of Postoperative Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis.Clinical cardiology · 2024Pooled it
- The efficacy and safety of intraoperative intravenous amiodarone in patients undergoing on-pump coronary artery bypass grafting surgery: a systemic review and PRISMA-compliant meta-analysis.Journal of cardiothoracic surgery · 2024Pooled it
- Differences in Postoperative Atrial Fibrillation Incidence and Outcomes After Cardiac Surgery According to Assessment Method and Definition: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- Surgical left atrial appendage occlusion in valvular heart disease without atrial fibrillation: the OPINION trial.European heart journal · 2026Trial
- Improving atrial fibrillation or flutter detection and management by smartphone-based photoplethysmography rhythm monitoring following cardiac surgery: a pragmatic randomized trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Trial
- A double-blind randomised controlled trial on the effect of Tocovid, a tocotrienol-rich capsule on postoperative atrial fibrillation at the National Heart Institute, Kuala Lumpur: an interim blinded analysis.Journal of cardiothoracic surgery · 2021Trial
- Effect of Continuous Electrocardiogram Monitoring on Detection of Undiagnosed Atrial Fibrillation After Hospitalization for Cardiac Surgery: A Randomized Clinical Trial.JAMA network open · 2021Trial
- New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting and Long-Term Outcome: A Population-Based Nationwide Study From the SWEDEHEART Registry.Journal of the American Heart Association · 2021Trial
- Perivascular fat attenuation index on coronary computed tomography angiography predicts postoperative atrial fibrillation after off-pump coronary artery bypass grafting.BMC cardiovascular disorders · 2026Article
- Plasma proteomics of extracellular vesicles identifies key proteins correlating to postoperative atrial fibrillation after coronary artery bypass surgery.Clinical proteomics · 2026Article
- Relative hyperglycemia and new-onset atrial fibrillation after coronary artery bypass grafting: a focus on stress hyperglycemia ratio.BMC cardiovascular disorders · 2025Article
- Impact of postoperative atrial fibrillation (POAF) on outcomes after coronary artery bypass grafting: A meta-analysis of unique 247,270 patients from 50 studies.American heart journal plus : cardiology research and practice · 2025Review
- Atlas of lysine propionylation of human right atrium and ALDH6A1-NADH pathway in new-onset atrial fibrillation after coronary surgery.Communications biology · 2025Article
- Postoperative atrial fibrillation following cardiac surgery in severe obesity: the added value of waist circumference.International journal of obesity (2005) · 2025Article
- Predictive Value of Age, Creatinine, and Ejection Fraction I and II Scores for Postoperative Atrial Fibrillation in Isolated On-Pump Coronary Artery Bypass Grafting Surgery: A Multicenter Retrospective Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Observational
- Feasibility and reliability of a smartwatch to detect atrial fibrillation after cardiac surgery: a prospective study.Frontiers in digital health · 2025Article
- Differential Expression of mRNA in Peripheral Blood Mononuclear Cells May Predict Postoperative Atrial Fibrillation in Coronary Artery Bypass Surgery Patients.Journal of cardiovascular translational research · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze (1) associations between postoperative atrial fibrillation (POAF) after CABG and long-term cardiovascular outcome, (2) whether associations were influenced by AF during follow-up, and (3) if morbidities associated with POAF contribute to mortality.
methodsAn observational cohort study of 7145 in-hospital survivors after isolated CABG (1996-2012), with preoperative sinus rhythm and without AF history. Incidence of AF was compared with matched controls. Time-updated covariates were used to adjust for POAF-related morbidities during follow-up, including AF.
resultsThirty-one percent of patients developed POAF. Median follow-up was 9.8 years. POAF patients had increased AF compared with matched controls (HR 3.03; 95% CI 2.66-3.49), while AF occurrence in non-POAF patients was similar to controls (1.00; 0.89-1.13). The observed AF increase among POAF patients compared with controls persisted over time (> 10 years 2.73; 2.13-3.51). Conversely, the non-POAF cohort showed no AF increase beyond the first postoperative year. Further, POAF was associated with long-term AF (adjusted HR 3.20; 95% CI 2.73-3.76), ischemic stroke (1.23; 1.06-1.42), heart failure (1.44; 1.27-1.63), overall mortality (1.21; 1.11-1.32), cardiac mortality (1.35; 1.18-1.54), and cerebrovascular mortality (1.54; 1.17-2.02). These associations remained after adjustment for AF during follow-up. Adjustment for other POAF-associated morbidities weakened the association between POAF and overall mortality, which became non-significant.
conclusionsPatients with POAF after CABG had three times the incidence of long-term AF compared with both non-POAF patients and matched controls. POAF was associated with long-term ischemic stroke, heart failure, and corresponding mortality even after adjustment for AF during follow-up. The increased overall mortality was partly explained by morbidities associated with POAF.
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