Evidence map›Paper›PMID 32036295›Full record

ReviewCurrent opinion in cell biology2020

From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells.

Coralie Trentesaux, Katharine Striedinger, Jason H Pomerantz, Ophir D Klein

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. ECM and epithelial stem cells: the scaffold of destiny.Frontiers in cell and developmental biology · 2024
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Coralie TrentesauxProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA.
Katharine StriedingerProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA.
Jason H PomerantzProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
Ophir D KleinProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA; Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, CA, USA. Electronic address: Ophir.Klein@ucsf.edu.

Funding

Harnessing natural stem cell-based strategies for mammalian dental renewalR35DE026602 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2016 to 2023
$8.0M
Regeneration and Differentiation Potential of Heterogeneous Human Satellite CellsR01AR072638 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POMERANTZ, JASON · 2017 to 2021
$1.7M
NIAMS NIH HHS R01 AR072638NIDCR NIH HHS R35 DE026602
6 · The paper itself

Abstract

Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states.

Indexed as

Adult Stem CellsCell DifferentiationGastrointestinal MicrobiomeHumansSignal TransductionStem Cell NicheCell signalingIntestinal stem cellsMuscle stem cells Satellite cellsStem cell nicheStem cells

Identifiers

PMID32036295
PMCPMC7247951

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.