Evidence map›Paper›PMID 32036005›Full record

ArticleInternational journal of radiation oncology, biology, physics2020

Protons Show Greater Relative Biological Effectiveness for Mammary Tumorigenesis with Higher ERα- and HER2-Positive Tumors Relative to γ-rays in APC

Shubhankar Suman, Igor Shuryak, Bhaskar Kallakury, David J Brenner, Albert J Fornace, Michael D Johnson, Kamal Datta

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shubhankar SumanLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.
Igor ShuryakCenter for Radiological Research, Columbia University, New York, New York.
Bhaskar KallakuryDepartment of Pathology, Georgetown University, Washington, DC.
David J BrennerCenter for Radiological Research, Columbia University, New York, New York.
Albert J FornaceLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC; Department Biochemistry and Molecular & Cellular Biology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.
Michael D JohnsonLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.
Kamal DattaLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC; Department Biochemistry and Molecular & Cellular Biology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC. Electronic address: kd257@georgetown.edu.
Georgetown University · USColumbia University · USGeorgetown University Medical Center · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
NCI NIH HHS P30 CA051008
6 · The paper itself

Abstract

purposeExposure to ionizing radiation increases risk of breast cancer. Although proton radiation is encountered in outer space and in medicine, we do not fully understand breast cancer risks from protons owing to limited in vivo data. The purpose of this study was to comparatively assess the effects of γ-rays and protons on mammary tumorigenesis in APC METHODS AND MATERIALS: Female APC

resultsExposure to proton radiation led to increased mammary tumor frequency at both proton radiation doses compared with γ-rays. The calculated relative biological effectiveness for proton radiation-induced mammary tumorigenesis was 3.11 for all tumors and >5 for malignant tumors relative to γ-rays. Tumor frequency per unit of radiation was higher at the lower dose, suggesting a saturation effect at the higher dose. Protons induced more adenocarcinomas relative to γ-rays, and proton-induced tumors show greater ERα and HER2 positivity and higher activation of the ERα downstream PI3K/Akt and cyclin D1 pathways relative to γ-rays.

conclusionsOur data demonstrate that protons pose a higher risk of mammary tumorigenesis relative to γ-rays. We also show that proton radiation-induced tumors in APC

Indexed as

Relative Biological EffectivenessAnimalsCarcinogenesisErb-b2 Receptor Tyrosine KinasesEstrogen Receptor alphaFemaleGamma RaysMammary Neoplasms, ExperimentalMiceProton TherapyErbb2 protein, mouseErb-b2 Receptor Tyrosine KinasesEstrogen Receptor alpha

Identifiers

PMID32036005
PMCPMC9835149
OpenAlexW3004499732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.