Evidence map›Paper›PMID 32035767›Full record

ArticleJournal of Ayurveda and integrative medicine

Tissue distribution of mercury and copper after Aarogyavardhini Vati treatment in rat model of CCl

Shrirang Jamadagni, Pallavi Jamadagni, Binita Angom, Dhirendranath Mondal, Sachchidanand Upadhyay, Sudesh Gaidhani, Jayram Hazra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shrirang JamadagniRegional Ayurveda Institute for Fundamental Research, Nehru Garden, Gandhi Bhawan Road, Kothrud, Pune, 411038, India. Electronic address: shrirangb@gmail.com.
Pallavi JamadagniRegional Ayurveda Institute for Fundamental Research, Nehru Garden, Gandhi Bhawan Road, Kothrud, Pune, 411038, India.
Binita AngomCentral Ayurveda Research Institute of Drug Development, 4CN, Sector -5, Bidhannagar, Kolkata, 700091, India.
Dhirendranath MondalCentral Ayurveda Research Institute of Drug Development, 4CN, Sector -5, Bidhannagar, Kolkata, 700091, India.
Sachchidanand UpadhyayCentral Ayurveda Research Institute of Drug Development, 4CN, Sector -5, Bidhannagar, Kolkata, 700091, India.
Sudesh GaidhaniCentral Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, 61-65, Institutional Area, Opposite D Block, Janakpuri, New Delhi, 110058, India.
Jayram HazraCentral Ayurveda Research Institute of Drug Development, 4CN, Sector -5, Bidhannagar, Kolkata, 700091, India.
Central Council for Research in Ayurvedic Science · INMinistry of AYUSH · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAarogyavardhini Vati is a classical Ayurvedic herbomineral formulation. It contains mercury and copper compounds as principal minerals along with other minerals and herbal ingredients. Aarogyavardhini Vati is indicated in chronic liver ailments. However, safety concerns are often raised regarding the use of mercury containing ayurvedic drugs in disease conditions due to the risk of mercury and copper toxicity.

objectiveThis study was performed to address the safety concerns regarding mercury and copper toxicity from Ayurvedic herbomineral formulations by investigating accumulation of these minerals in tissues and subsequent toxicity in chronic hepatotoxicity rat model. MATERIALS AND

methodsQuantification of mercury and copper in Aarogyavardhini Vati was done. Chronic hepatotoxicity was induced in the Wistar rats by repeated administration of CCl

resultsTreatment with Aarogyavardhini Vati exhibited significant accumulation of mercury in the kidney but not in the brain and liver. Similarly, no significant accumulation of copper was observed in liver, kidney, and brain due to the treatment of Aarogyavardhini Vati. Serum biochemical and histopathological changes were not affected by the treatment with Aarogyavardhini Vati.

conclusionAarogyavardhini Vati did not show any biologically significant potential to cause toxicity due to its mercury and copper content when administered for prolonged duration to rats with chronic hepatotoxicity.

Indexed as

Aarogyavardhini VatiCopperMercuryRatSafetyTissue distribution

Identifiers

PMID32035767
PMCPMC7772489
OpenAlexW3004424081

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.